de la Fuente M, Peñas P F, Sols A
Biochem Biophys Res Commun. 1986 Oct 15;140(1):51-5. doi: 10.1016/0006-291x(86)91056-9.
Mannose toxicity in honeybees is due to a marked shortage of mannosephosphate isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have excess of mannosephosphate isomerase over hexokinase. 2-Deoxyglucose is as toxic as mannose for honeybees and is toxic also for the other insects studied, which supports the conclusion that the mechanism of mannose toxicity involves large accumulation of a hexosephosphate.
蜜蜂体内的甘露糖毒性是由于磷酸甘露糖异构酶严重缺乏，导致6-磷酸甘露糖大量积累以及ATP显著消耗。黑腹果蝇和地中海实蝇对甘露糖不敏感，其磷酸甘露糖异构酶的含量超过己糖激酶。2-脱氧葡萄糖对蜜蜂的毒性与甘露糖相同，对其他所研究的昆虫也有毒性，这支持了甘露糖毒性机制涉及己糖磷酸大量积累的结论。
