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Allergol Int. 2019 Jan;68(1):1-3. doi: 10.1016/j.alit.2018.12.002.
2
Prospects on the Use of sp. to Develop Oral Vaccines.关于利用[具体物种名称]开发口服疫苗的前景。 （注：原文中“sp.”可能代表某个特定物种，这里按常规翻译方式处理，但需结合具体语境确定准确物种名）
Front Microbiol. 2018 Oct 25;9:2506. doi: 10.3389/fmicb.2018.02506. eCollection 2018.
3
Protection against human papillomavirus type 16-induced tumors in C57BL/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein.通过黏膜接种表达 E6 癌蛋白的 Lactococcus lactis NZ9000 预防 C57BL/6 小鼠感染人乳头瘤病毒 16 型诱导的肿瘤。
Microb Pathog. 2019 Jan;126:149-156. doi: 10.1016/j.micpath.2018.10.043. Epub 2018 Nov 2.
4
Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.通过针对流感血凝素的多结构域抗体实现对流感感染的普遍保护。
Science. 2018 Nov 2;362(6414):598-602. doi: 10.1126/science.aaq0620.
5
Update on Vaccine-Derived Polioviruses - Worldwide, January 2017-June 2018.疫苗衍生脊灰病毒最新情况——全球，2017 年 1 月至 2018 年 6 月。
MMWR Morb Mortal Wkly Rep. 2018 Oct 26;67(42):1189-1194. doi: 10.15585/mmwr.mm6742a5.
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黏膜疫苗和技术。

Mucosal vaccines and technology.

机构信息

Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, UK.

Department of Infection Biology, University of Liverpool, Liverpool, UK.

出版信息

Clin Exp Immunol. 2019 May;196(2):205-214. doi: 10.1111/cei.13285. Epub 2019 Apr 8.

DOI:10.1111/cei.13285
PMID:30963541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6468177/
Abstract

There is an urgent and unmet need to develop effective vaccines to reduce the global burden of infectious disease in both animals and humans, and in particular for the majority of pathogens that infect via mucosal sites. Here we summarise the impediments to developing mucosal vaccines and review the new and emerging technologies aimed at overcoming the lack of effective vaccine delivery systems that is the major obstacle to developing new mucosal vaccines.

摘要

目前迫切需要开发有效的疫苗，以减轻动物和人类传染病的全球负担，特别是针对大多数通过粘膜部位感染的病原体。在这里，我们总结了开发粘膜疫苗的障碍，并回顾了旨在克服缺乏有效疫苗输送系统的新技术，这是开发新的粘膜疫苗的主要障碍。