黏膜疫苗和技术。
Mucosal vaccines and technology.
机构信息
Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, UK.
Department of Infection Biology, University of Liverpool, Liverpool, UK.
出版信息
Clin Exp Immunol. 2019 May;196(2):205-214. doi: 10.1111/cei.13285. Epub 2019 Apr 8.
Abstract
There is an urgent and unmet need to develop effective vaccines to reduce the global burden of infectious disease in both animals and humans, and in particular for the majority of pathogens that infect via mucosal sites. Here we summarise the impediments to developing mucosal vaccines and review the new and emerging technologies aimed at overcoming the lack of effective vaccine delivery systems that is the major obstacle to developing new mucosal vaccines.
摘要
目前迫切需要开发有效的疫苗，以减轻动物和人类传染病的全球负担，特别是针对大多数通过粘膜部位感染的病原体。在这里，我们总结了开发粘膜疫苗的障碍，并回顾了旨在克服缺乏有效疫苗输送系统的新技术，这是开发新的粘膜疫苗的主要障碍。
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