State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Food Funct. 2019 May 22;10(5):2417-2425. doi: 10.1039/c8fo01089g.
d-Psicose is a new-generation sugar substitute with a low calorie count and can still offer the desirable sweetness. The objective of this study was to investigate the antiobesity potential of d-psicose and the possible mechanism using Wistar rats as the animal model. The animals were divided into five groups and supplemented with diets containing 5% of different carbohydrates, such as glucose, fructose, cellulose, d-psicose, and a control diet, for 4 weeks. After sacrifice, blood lipid profile, tissue morphology, and related genes participating in lipid metabolism were analyzed. The results indicated that the supplementation by d-psicose leads to minimum fat accumulation in rats when compared with the other carbohydrates. The blood lipid profile and antioxidative activity of the rat were also improved. d-Psicose can regulate lipid metabolism by increasing the lipid-metabolism-related enzymes such as SDH in serum and liver and HL in the liver. d-Psicose can prevent fat accumulation by suppressing the expression of lipogenesis-related gene ACCα and hepatic fatty acid uptake gene (FAS and SREBP-1c), while stimulating the expression for fatty-acid-oxidation-related gene including AMPK2α, HSL, and PPARα. In conclusion, d-psicose can be considered to be a healthy alternative to traditional sweeteners.
d-阿洛酮糖是一种低卡路里的新一代代糖，仍然可以提供令人满意的甜度。本研究的目的是使用 Wistar 大鼠作为动物模型，研究 d-阿洛酮糖的抗肥胖潜力及其可能的机制。动物被分为五组，并用含有 5%不同碳水化合物的饮食补充，如葡萄糖、果糖、纤维素、d-阿洛酮糖和对照饮食，持续 4 周。处死动物后，分析血脂谱、组织形态和参与脂质代谢的相关基因。结果表明，与其他碳水化合物相比，d-阿洛酮糖的补充导致大鼠体内脂肪积累最少。大鼠的血脂谱和抗氧化活性也得到了改善。d-阿洛酮糖可以通过增加血清和肝脏中的脂质代谢相关酶（如 SDH 和 HL）以及肝脏中的 HL 来调节脂质代谢。d-阿洛酮糖可以通过抑制脂生成相关基因 ACCα 和肝脂肪酸摄取基因（FAS 和 SREBP-1c）的表达，同时刺激包括 AMPK2α、HSL 和 PPARα 在内的脂肪酸氧化相关基因的表达来防止脂肪积累。总之，d-阿洛酮糖可以被认为是传统甜味剂的健康替代品。
