Pharmaceutical Research Inst, CJ CheilJedang Corp, Ichon, Kyonggi-do 467-812, Korea.
J Food Sci. 2012 Feb;77(2):H53-8. doi: 10.1111/j.1750-3841.2011.02571.x.
D-Psicose, a C-3 epimer of D-fructose, has shown promise in reducing body fat accumulation in normal rats and plasma glucose level in genetic diabetic mice. Effects of D-psicose on diet-induced obesity are not clearly elucidated, and we investigated food intake, body weight, and fat accumulation in rats fed high-fat (HF) diet. Sprague-Dawley rats became obese by feeding HF diet for 4 wk, and were assigned either to normal or HF diet supplemented with or without D-psicose, sucrose, or erythritol for 8 wk. Changing HF to normal diet gained less body weight and adipose tissue due to different energy intake. D-psicose-fed rats exhibited lower weight gain, food efficiency ratio, and fat accumulation than erythritol- and sucrose-fed rats. This effect was more prominent in D-psicose-fed rats with normal diet than with HF diet, suggesting combination of psicose and calorie restriction further reduced obesity. There was no difference in serum cholesterol/high-density lipoprotein (HDL)-C and low-density lipoprotein (LDL)-C/HDL-C ratios between D-psicose group and other groups. Liver weight in 5% psicose group with normal diet was higher than in other groups, but histopathological examination did not reveal any psicose-related change. D-Psicose inhibited the differentiation of mesenchymal stem cell (MSC) to adipose tissue in a concentration-dependent manner. These results demonstrate that D-psicose produces a marked decrease, greater than erythritol, in weight gain and visceral fat in an established obesity model by inhibiting MSC differentiation to adipocyte. Thus, D-psicose can be useful in preventing and reducing obesity as a sugar substitute and food ingredient.
We can develop D-psicose as a sugar substitute and food ingredient since it can prevent obesity in normal people, but also suppress adiposity as a sugar substitute or food ingredients with antiobesity effect in obese people. D-psicose can be unique functional sweetener because of its function of reducing visceral fat mass and weight gain.
D-阿洛酮糖，D-果糖的 C-3 差向异构体，已显示出在减少正常大鼠体脂肪积累和遗传糖尿病小鼠血浆葡萄糖水平方面的潜力。D-阿洛酮糖对饮食诱导肥胖的影响尚不清楚，我们研究了高脂肪（HF）饮食喂养大鼠的食物摄入量、体重和脂肪积累。Sprague-Dawley 大鼠通过喂养 HF 饮食 4 周而肥胖，并被分配到正常或 HF 饮食中，或补充 D-阿洛酮糖、蔗糖或赤藓糖醇，持续 8 周。由于能量摄入不同，将 HF 改为正常饮食会使体重和脂肪组织增加减少。与赤藓糖醇和蔗糖喂养的大鼠相比，D-阿洛酮糖喂养的大鼠体重增加、食物效率比和脂肪积累较低。在 D-阿洛酮糖喂养的正常饮食大鼠中，这种效果比 HF 饮食大鼠更为明显，这表明阿洛酮糖和热量限制的结合进一步减少了肥胖。D-阿洛酮糖组与其他组之间的血清胆固醇/高密度脂蛋白（HDL）-C 和低密度脂蛋白（LDL）-C/HDL-C 比值没有差异。正常饮食 5%阿洛酮糖组的肝重高于其他组，但组织病理学检查未发现与阿洛酮糖相关的变化。D-阿洛酮糖以浓度依赖的方式抑制间充质干细胞（MSC）向脂肪组织的分化。这些结果表明，D-阿洛酮糖通过抑制 MSC 向脂肪细胞的分化，在已建立的肥胖模型中产生比赤藓糖醇更大的体重增加和内脏脂肪减少。因此，D-阿洛酮糖可用作预防和减少肥胖的糖替代品和食品成分。
我们可以开发 D-阿洛酮糖作为糖替代品和食品成分，因为它可以预防正常人肥胖，而且作为肥胖人群的减肥效果的糖替代品或食品成分，也可以抑制肥胖。由于其减少内脏脂肪量和体重增加的功能，D-阿洛酮糖可以成为独特的功能性甜味剂。
