Department of Dermatology and Venerology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Dermatol Ther. 2019 May;32(3):e12903. doi: 10.1111/dth.12903. Epub 2019 Apr 25.
Janus kinase-signal transducer and activator of transcription (JAK/STAT)-is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Several molecules that modulate-inhibit-this pathway are currently under investigation for the evaluation of their clinical use in dermatological diseases. A brief overview of the therapeutical use of JAK/STAT inhibitors in dermatology will be provided here.
Janus 激酶-信号转导子和转录激活子（JAK/STAT）-是细胞内信号通路，在将细胞外信号从细胞膜传递到细胞核的下游传递中起关键作用。该途径由细胞因子激活，细胞因子参与炎症、先天和获得性免疫反应以及细胞生长。最近的研究指出，JAK/STAT 通路在各种炎症性和自身免疫性皮肤病中可能存在紊乱，例如特应性皮炎、银屑病、斑秃。目前正在研究几种调节-抑制-该途径的分子，以评估其在皮肤科疾病中的临床应用。本文将简要概述 JAK/STAT 抑制剂在皮肤科中的治疗用途。
