Raychaudhuri Siba P, Raychaudhuri Smriti K
Department of Dermatology and of Medicine/Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, UC Davis, CA, United States.
Department of Veterans Affairs, VA Sacramento Medical Center, Northern California Health Care, California, CA, United States.
Indian J Dermatol Venereol Leprol. 2023 Sep-Oct;89(5):688-690. doi: 10.25259/IJDVL_8_2023.
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a key regulatory signaling system for cellular proliferation, differentiation, and apoptosis. In addition, JAK signaling pathway plays critical roles in orchestrating immune response through its interactions with the cytokine receptors and the transcriptions factors. Several key cytokines use JAK-STAT signaling proteins to transduce intra-cellular signals which are involved in the pathogenesis of autoimmune and inflammatory diseases such as in psoriatic disease (psoriasis, psoriatic arthritis), atopic dermatitis, alopecia areata, vitiligo, rheumatoid arthritis, ankylosing spondylitis, lupus erythematosus, Sjogren's syndrome, and other autoimmune diseases. In recent years, understandings of the molecular mechanisms of JAK-STAT pathway in the inflammatory proliferative cascades of autoimmune diseases has led to the development of JAK inhibitors and has opened a new dimension for the treatment of systemic and cutaneous inflammatory diseases. In this symposium we have provided a broad perspective on the use of Janus kinase inhibitors in cutaneous autoimmune diseases.
Janus激酶（JAK）-信号转导及转录激活因子（STAT）通路是细胞增殖、分化和凋亡的关键调控信号系统。此外，JAK信号通路通过与细胞因子受体和转录因子相互作用，在协调免疫反应中发挥关键作用。几种关键细胞因子利用JAK-STAT信号蛋白转导细胞内信号，这些信号参与自身免疫性疾病和炎症性疾病的发病机制，如银屑病（牛皮癣、银屑病关节炎）、特应性皮炎、斑秃、白癜风、类风湿性关节炎、强直性脊柱炎、红斑狼疮、干燥综合征及其他自身免疫性疾病。近年来，对JAK-STAT通路在自身免疫性疾病炎症增殖级联反应中分子机制的认识推动了JAK抑制剂的研发，并为系统性和皮肤炎症性疾病的治疗开辟了新领域。在本次研讨会上，我们对Janus激酶抑制剂在皮肤自身免疫性疾病中的应用进行了全面展望。
