用于氢化可的松口腔给药的卡波姆/聚（2-乙基-2-恶唑啉）粘膜粘附片的制剂

Formulation of Carbopol/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone.

作者信息

Ruiz-Rubio Leire, Alonso María Luz, Pérez-Álvarez Leyre, Alonso Rosa Maria, Vilas Jose Luis, Khutoryanskiy Vitaliy V

机构信息

Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain.

Analytical Chemistry Department, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain.

出版信息

Polymers (Basel). 2018 Feb 11;10(2):175. doi: 10.3390/polym10020175.

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.