Haußmann Robert, Sauer Cathrin, Neumann Stefanie, Zweiniger Anne, Lange Jan, Donix Markus
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
Standort Dresden, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Dresden, Deutschland.
Nervenarzt. 2019 Nov;90(11):1162-1169. doi: 10.1007/s00115-019-0710-x.
Vitamin B12 and folic acid deficiencies are particularly frequent conditions in older people. Since these metabolic disorders represent relevant dyscognitive factors, the assessment of vitamin B12 and folic acid levels is essential in the diagnostic approach of cognitive disorders, such as mild cognitive impairment and dementia in an outpatient memory clinic. This article summarizes the relevant diagnostic and therapeutic aspects of vitamin B12 and folic acid deficiencies and their effects on cognition. The literature review is supplemented by a data analysis of a naturalistic cohort of 250 patients from this outpatient memory clinic.
维生素B12和叶酸缺乏在老年人中是特别常见的情况。由于这些代谢紊乱是相关的认知障碍因素，在门诊记忆诊所对轻度认知障碍和痴呆等认知障碍进行诊断时，评估维生素B12和叶酸水平至关重要。本文总结了维生素B12和叶酸缺乏的相关诊断和治疗方面及其对认知的影响。通过对该门诊记忆诊所250名患者的自然队列进行数据分析，对文献综述进行了补充。
