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一名患有过敏性紫癜并伴有急性风湿热的女孩及文献综述

A girl with Henoch Schönlein purpura associated with acute rheumatic fever and review of literature.

作者信息

Aypar Ebru, Demirtaş Duygu, Aykan Hayrettin Hakan, Kara-Eroğlu Fehime, Düzova Ali

机构信息

Division of Pediatric Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

出版信息

Turk J Pediatr. 2018;60(5):576-580. doi: 10.24953/turkjped.2018.05.017.

DOI:10.24953/turkjped.2018.05.017
PMID:30968630
Abstract

Aypar E, Demirtaş D, Aykan HH, Kara-Eroğlu F, Düzova A. A girl with Henoch Schönlein purpura associated with acute rheumatic fever and review of literature. Turk J Pediatr 2018; 60: 576-580. Henoch Schönlein purpura (HSP) with acute rheumatic fever (ARF) is a rare entity and only few cases have been reported so far. In all previously reported cases with HSP and ARF, patients initially presented with purpuric rash, arthralgia/arthritis, or abdominal pain and later diagnosed as ARF. We report an 11-year-old girl with features of both ARF and HSP. She initially presented with arthralgia and murmur. Echocardiography showed mild to moderate mitral regurgitation. Later, the clinical course was complicated by purpuric rash and abdominal pain. She was treated conservatively with IM penicillin, acetylsalicylic acid and oral prednisolone. Our patient is the first patient with HSP and ARF who initially presented with features of ARF. A review of literature revealed a limited number of cases of HSP associated with ARF (14 cases including the present case); and that the response to treatment in cases suffering from ARF associated with HSP was good; but one should also be aware of serious cardiac complications in HSP patients which may be fatal.

摘要

艾帕尔·E、德米尔塔什·D、艾坎·H·H、卡拉-埃罗卢·F、迪佐娃·A。一名患有与急性风湿热相关的过敏性紫癜的女孩及文献综述。《土耳其儿科学杂志》2018年;60:576 - 580。伴有急性风湿热(ARF)的过敏性紫癜(HSP)是一种罕见情况,迄今为止仅有少数病例报道。在所有先前报道的患有HSP和ARF的病例中,患者最初表现为紫癜性皮疹、关节痛/关节炎或腹痛,随后被诊断为ARF。我们报告一名11岁女孩,同时具有ARF和HSP的特征。她最初表现为关节痛和杂音。超声心动图显示轻度至中度二尖瓣反流。后来,临床病程因紫癜性皮疹和腹痛而复杂化。她接受了肌内注射青霉素、乙酰水杨酸和口服泼尼松龙的保守治疗。我们的患者是首例最初表现为ARF特征的HSP和ARF患者。文献综述显示,与ARF相关的HSP病例数量有限(包括本病例在内共14例);并且患有与HSP相关的ARF的病例对治疗反应良好;但也应注意HSP患者可能出现的严重心脏并发症,这可能是致命的。

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