Ghannam N, Kingston M, Al-Meshaal I A, Tariq M, Parman N S, Woodhouse N
Horm Res. 1986;24(4):288-94. doi: 10.1159/000180569.
The dried sap of the aloe plant (aloes) is one of several traditional remedies used for diabetes in the Arabian peninsula. Its ability to lower the blood glucose was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. During the ingestion of aloes, half a teaspoonful daily for 4-14 weeks, the fasting serum glucose level fell in every patient from a mean of 273 +/- 25 (SE) to 151 +/- 23 mg/dl (p less than 0.05) with no change in body weight. In normal mice, both glibenclamide (10 mg/kg twice daily) and aloes (500 mg/kg twice daily) induced hypoglycaemia after 5 days, 71 +/- 6.2 and 91 +/- 7.6 mg/dl, respectively, versus 130 +/- 7 mg/dl in control animals (p less than 0.01); only glibenclamide was effective after 3 days. In the diabetic mice, fasting plasma glucose was significantly reduced by glibenclamide and aloes after 3 days. Thereafter only aloes was effective and by day 7 the plasma glucose was 394 +/- 22.0 versus 646 +/- 35.9 mg/dl, in the controls and 726 +/- 30.9 mg/dl in the glibenclamide treated group (p less than 0.01). We conclude that aloes contains a hypoglycaemic agent which lowers the blood glucose by as yet unknown mechanisms.
芦荟植物的干汁液（芦荟）是阿拉伯半岛用于治疗糖尿病的几种传统药物之一。研究人员在5名非胰岛素依赖型糖尿病患者以及用四氧嘧啶诱导糖尿病的瑞士白化小鼠身上，对其降低血糖的能力进行了研究。在服用芦荟期间，每天半茶匙，持续4至14周，每位患者的空腹血清葡萄糖水平均从平均273±25（标准误）降至151±23毫克/分升（p<0.05），体重未发生变化。在正常小鼠中，格列本脲（每日两次，每次10毫克/千克）和芦荟（每日两次，每次500毫克/千克）在5天后均诱导低血糖，分别为71±6.2和91±7.6毫克/分升，而对照组动物为130±7毫克/分升（p<0.01）；仅格列本脲在3天后有效。在糖尿病小鼠中，格列本脲和芦荟在3天后均能显著降低空腹血糖。此后，只有芦荟有效，到第7天时，血浆葡萄糖水平在对照组为646±35.9毫克/分升，格列本脲治疗组为726±30.9毫克/分升，而芦荟治疗组为394±22.0毫克/分升（p<0.01）。我们得出结论，芦荟含有一种降血糖剂，其通过尚未明确的机制降低血糖。
