Skin Care Physicians of Georgia, Macon, GA, USA.
Mercer University School of Medicine, Macon, GA, USA.
J Dermatolog Treat. 2021 Feb;32(1):117-119. doi: 10.1080/09546634.2019.1628170. Epub 2019 Jul 5.
Acrodermatitis continua of hallopeau (ACH) is a rare chronic inflammatory variant of pustular psoriasis often restricted to the distal portions the digits in the hands and feet. ACH is of a chronic relapsing nature and is invariably recalcitrant to many available topical and systemic anti-psoriatic therapies. On account of its low prevalence and high resistance to treatments, no clinical guideline of ACH exists. We present a patient with ACH resistant to multiple therapies, including the biologic adalimumab, who was successfully treated with an IL-17 inhibitor (ixekizumab). We believe our unique treatment with an excellent outcome may assist other dermatologists if faced with this condition.
掌跖脓疱性银屑病（Acrodermatitis continua of hallopeau，ACH）是一种罕见的慢性炎症性脓疱型银屑病变异型，通常局限于手部和脚部的远端指（趾）。ACH 具有慢性复发性，并且对许多可用的局部和全身抗银屑病治疗均具有抗性。由于其患病率低且对治疗的抵抗力高，ACH 目前尚无临床指南。我们报告了一例 ACH 患者，该患者对多种治疗方法（包括生物制剂阿达木单抗）均有耐药性，后成功接受了 IL-17 抑制剂（依奇珠单抗）治疗。我们相信，如果其他皮肤科医生遇到这种情况，我们独特的治疗方法和极佳的疗效可能会有所帮助。
