Pekel Gökhan, Taşçı Murat, Bahar Alperen, Pekel Evre, Çetin Ebru Nevin, Martin Çiğdem, Çobankara Veli
Ophthalmology Department, Pamukkale University, Denizli, Turkey.
Rheumatology Division, Pamukkale University, Denizli, Turkey.
Arq Bras Oftalmol. 2019 Jul-Aug;82(4):270-274. doi: 10.5935/0004-2749.20190054. Epub 2019 Apr 8.
We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals.
Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comparative study. The thickness of the pre-ocular tear film, corneal epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium were measured on the corneal apex. Anterior scleral thickness was measured at distances of 1 mm and 3 mm from the limbus. The anterior segment module of spectral-domain optical coherence tomography was used to measure thicknesses of pre-ocular tear film, corneal layers, and anterior sclera.
Tear film thickness, Schirmer's test, and tear break up time values were significantly lower in the Sjögren's disease group than in the healthy controls (p<0.05). The thickness measurements of corneal layers and sclera were similar between the groups. Tear film thickness was moderately correlated with the Schirmer's test results (r=0.34, p=0.001), but there was no correlation between the Schirmer's test results and tear break up time (r=0.18, p=0.09).
Pre-ocular tear film, as measured by anterior segment optical coherence tomography, was thinner in patients with primary Sjögren's syndrome than in the healthy controls. The thicknesses of corneal layers and anterior sclera were similar between the groups.
我们旨在比较原发性干燥综合征患者与健康个体之间的前巩膜厚度、角膜各层厚度以及眼前泪膜厚度。
在这项横断面比较研究中，招募了51例原发性干燥综合征患者和41名健康对照者。在角膜顶点测量眼前泪膜、角膜上皮、Bowman层、基质、Descemet膜和内皮的厚度。在距角膜缘1mm和3mm处测量前巩膜厚度。使用光谱域光学相干断层扫描的眼前节模块测量眼前泪膜、角膜各层和前巩膜的厚度。
干燥综合征组的泪膜厚度、Schirmer试验和泪膜破裂时间值显著低于健康对照组（p<0.05）。两组之间角膜各层和巩膜的厚度测量结果相似。泪膜厚度与Schirmer试验结果中度相关（r=0.34，p=0.001），但Schirmer试验结果与泪膜破裂时间之间无相关性（r=0.18，p=0.09）。
通过眼前节光学相干断层扫描测量，原发性干燥综合征患者的眼前泪膜比健康对照组更薄。两组之间角膜各层和前巩膜的厚度相似。
