Xu W W, Zhang H, Su J, Wang S, Feng J
Department of Otorhinolaryngology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Autonomous Region, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug 7;56(8):819-823. doi: 10.3760/cma.j.cn115330-202000902-00716.
To explore the correlation between eosinophils (Eos) and the incidence of chronic sinusitis with nasal polyps (CRSwNP) in Xinjiang region of China by comparing the proportion of inflammatory cells in the pathological tissues and peripheral blood. Retrospective analysis was performed on 582 patients with CRSwNP who underwent endoscopic nasal surgery in the First Affiliated Hospital of Xinjiang Medical University from January 2012 to March 2018, including 367 males and 215 females, aged (45.5±13.4) years (x¯±s). Patients were divided into groups according to demographic characteristics, recurrence and complication of allergic rhinitis (AR). Preoperative blood routine and postoperative pathological section data of nasal polyps were collected to compare the ratio of inflammatory cells in pathological tissue and the ratio of peripheral blood Eos in each group. The correlation between the proportion of inflammatory cells in the pathological tissue of nasal polyps and the recurrence of CRSwNP was analyzed, as well as the distribution of (eosCRSwNP) in Uygur and Han CRSwNP patients in Xinjiang region. Statistical analysis was performed by SPSS 19.0 software. Compared with non-recurrent CRSwNP patients, the ratio of Eos in nasal polyp tissue and peripheral blood was increased significantly, ( value was -3.142 and -2.344, respectively, both <0.05). Compared with CRSwNP patients without AR, the ratio of Eos in nasal polyps and peripheral blood was also increased significantly in patients with AR ( value was -6.664 and -4.520, respectively, both <0.05). There was a positive correlation between tissue Eos and CRSwNP recurrence (=0.130, =0.002). The majority of CRSwNP patients were both eosCRSwNP in Uygur and Han ethnic groups. Eos is associated with the recurrence of CRSwNP in Xinjiang region, and eosCRSwNP is the dominant factor in both Uygur and Han patients.
通过比较病理组织和外周血中炎症细胞的比例，探讨嗜酸性粒细胞（Eos）与中国新疆地区慢性鼻窦炎伴鼻息肉（CRSwNP）发病率之间的相关性。对2012年1月至2018年3月在新疆医科大学第一附属医院接受鼻内镜手术的582例CRSwNP患者进行回顾性分析，其中男性367例，女性215例，年龄（45.5±13.4）岁（x¯±s）。根据人口统计学特征、变应性鼻炎（AR）的复发情况和并发症将患者分组。收集术前血常规和术后鼻息肉病理切片数据，比较各组病理组织中炎症细胞比例和外周血Eos比例。分析鼻息肉病理组织中炎症细胞比例与CRSwNP复发的相关性，以及新疆地区维吾尔族和汉族CRSwNP患者中嗜酸性粒细胞性慢性鼻窦炎（eosCRSwNP）的分布情况。采用SPSS 19.0软件进行统计学分析。与非复发性CRSwNP患者相比，鼻息肉组织和外周血中Eos比例显著升高（值分别为-3.142和-2.344，均<0.05）。与无AR的CRSwNP患者相比，有AR的患者鼻息肉和外周血中Eos比例也显著升高（值分别为-6.664和-4.520，均<0.05）。组织Eos与CRSwNP复发呈正相关（=0.130，=0.002）。维吾尔族和汉族CRSwNP患者中大多数均为eosCRSwNP。Eos与新疆地区CRSwNP的复发相关，eosCRSwNP在维吾尔族和汉族患者中均为主要因素。
