通过电驱动薄膜拉伸实现微泡向串珠状纳米纤维的可控变形

Yao Zhi-Cheng, Yuan Qiantailang, Ahmad Zeeshan, Huang Jie, Li Jing-Song, Chang Ming-Wei

Key Laboratory for Biomedical Engineering of Education, Ministry of China, Hangzhou 310027, China.

Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China.

Polymers (Basel). 2017 Jul 3;9(7):265. doi: 10.3390/polym9070265.

Topography and microstructure engineering are rapidly evolving areas of importance for biomedical and pharmaceutical remits. Here, PVA (Polyvinyl alcohol) microbubbles (diameter range ~126 to 414 μm) were used to fabricate beaded (beads-on) nanofibers using an electrohydrodynamic atomization (EHDA) technique. Mean fiber diameter, inter-bead distance, and aspect ratio (AR) were investigated by regulating EHDA process parameters. PVA fibers (diameter range ~233 to 737 nm) were obtained possessing bead ARs in the range of ~10 to 56%. AR was used to modulate hydrophilicity and active release.

形貌和微观结构工程是生物医学和制药领域中迅速发展且至关重要的领域。在此，使用聚乙烯醇（PVA）微泡（直径范围约为126至414μm）通过电流体动力学雾化（EHDA）技术制备珠状（珠上）纳米纤维。通过调节EHDA工艺参数来研究平均纤维直径、珠间距离和纵横比（AR）。获得了直径范围约为233至737nm的PVA纤维，其珠状纵横比在约10%至56%的范围内。纵横比用于调节亲水性和活性释放。