Taabache Soraya, Bertin Annabelle
Federal Institute for Materials Research and Testing (BAM), Department 6.0, D-12205 Berlin, Germany.
Fraunhofer ICT-IMM, D-55129 Mainz, Germany.
Polymers (Basel). 2017 Jul 12;9(7):280. doi: 10.3390/polym9070280.
The current review focuses on vesicles obtained from the self-assembly of two types of dendritic macromolecules, namely amphiphilic Janus dendrimers (forming dendrimersomes) and amphiphilic dumbbells. In the first part, we will present some synthetic strategies and the various building blocks that can be used to obtain dendritic-based macromolecules, thereby showing their structural versatility. We put our focus on amphiphilic Janus dendrimers and amphiphilic dumbbells that form vesicles in water but we also encompass vesicles formed thereof in organic solvents. The second part of this review deals with the production methods of these vesicles at the nanoscale but also at the microscale. Furthermore, the influence of various parameters (intrinsic to the amphiphilic JD and extrinsic-from the environment) on the type of vesicle formed will be discussed. In the third part, we will review the numerous biomedical applications of these vesicles of nano- or micron-size.
当前综述聚焦于由两类树枝状大分子自组装得到的囊泡，即两亲性Janus树枝状大分子（形成树枝状大分子囊泡）和两亲性哑铃状分子。在第一部分，我们将介绍一些合成策略以及可用于获得基于树枝状大分子的大分子的各种构建单元，从而展示它们的结构多样性。我们重点关注在水中形成囊泡的两亲性Janus树枝状大分子和两亲性哑铃状分子，但也包括它们在有机溶剂中形成的囊泡。本综述的第二部分涉及这些囊泡在纳米尺度以及微米尺度的制备方法。此外，还将讨论各种参数（两亲性Janus树枝状大分子的内在参数以及来自环境的外在参数）对所形成囊泡类型的影响。在第三部分，我们将综述这些纳米或微米尺寸囊泡的众多生物医学应用。
