Souvatzoglou A, Voulgaris Z, Charitopoulou R, Rapti E
J Endocrinol Invest. 1986 Aug;9(4):325-30. doi: 10.1007/BF03346936.
The efficacy of iv and sc chronic GnRH administration with different pulsatile patterns (15 micrograms every 90 min and 7.8 micrograms every 90 min with minor intermediate pulses of 2.3 micrograms every 22.2 min) by means of portable pumps were evaluated in a patient with primary hypothalamic amenorrhea. Observations of the amplitude and duration of the induced serum gonadotropin concentrations, of follicular growth (via ultrasound), and of ovarian steroids were made. Iv delivery of GnRH, 15 micrograms every 90 min, induced a normal menstrual cycle. Dividing this dose, as described above, giving it iv and sc, resulted in inappropriate gonadotropin secretion (overstimulation and desensitization, respectively) and arrest of follicular development. Sc delivery of 15 micrograms GnRH every 90 min resulted in an insufficient LH stimulation.
通过便携式泵以不同脉冲模式（每90分钟15微克和每90分钟7.8微克，每隔22.2分钟有2.3微克的小的中间脉冲）静脉内和皮下慢性给予促性腺激素释放激素（GnRH），对一名原发性下丘脑闭经患者的疗效进行了评估。观察了诱导的血清促性腺激素浓度的幅度和持续时间、卵泡生长（通过超声）以及卵巢类固醇。每90分钟静脉内给予15微克GnRH可诱导正常月经周期。如上所述将该剂量分开，静脉内和皮下给药，导致促性腺激素分泌不当（分别为过度刺激和脱敏）以及卵泡发育停滞。每90分钟皮下给予15微克GnRH导致促黄体生成素（LH）刺激不足。
