Reid R L, Leopold G R, Yen S S
Fertil Steril. 1981 Nov;36(5):553-9. doi: 10.1016/s0015-0282(16)45850-4.
The efficacy of intravenous and subcutaneous routes for pulsatile delivery of differing dosages of synthetic luteinizing hormone releasing factor (LRF) for ovulation induction were evaluated sequentially in two patients with presumed deficiency of endogenous LRF: isolated gonadotropin deficiency and pituitary stalk transection with hyperprolactinemia. Observations were made of the amplitude and duration of the induced LH-FSH pulses, of follicular growth and ovulation (via ultrasound), and of ovarian steroids. Remarkable differences in each of these parameters were found between the two modes of LRF delivery. LRF pulses administered subcutaneously resulted in inappropriate gonadotropin secretion, arrest of follicular development, elevated ratios of E1/E2 and androgens/estrogens, and the appearance of acne - features of polycystic ovary syndrome. In contrast, the first intravenous course of pulsatile LRF induced orderly follicular maturation and ovulation with subsequent pregnancy in both subjects. From these findings we conclude that, in these patients, the intravenous mode of delivery of LRF pulses was superior to the subcutaneous route at all doses tested.
在两名推测存在内源性促黄体生成素释放因子（LRF）缺乏的患者中，依次评估了静脉内和皮下途径脉冲式给予不同剂量合成LRF用于诱导排卵的疗效：分别为孤立性促性腺激素缺乏症患者和伴有高泌乳素血症的垂体柄横断患者。观察了诱导的促黄体生成素 - 促卵泡生成素（LH - FSH）脉冲的幅度和持续时间、卵泡生长和排卵情况（通过超声检查）以及卵巢甾体激素水平。发现两种LRF给药方式在这些参数中的每一项上都存在显著差异。皮下注射LRF脉冲导致促性腺激素分泌异常、卵泡发育停滞、雌酮/雌二醇（E1/E2）和雄激素/雌激素比值升高以及痤疮出现——这些都是多囊卵巢综合征的特征。相比之下，首次静脉内脉冲式给予LRF诱导了两名受试者的卵泡有序成熟和排卵，随后均成功妊娠。从这些发现中我们得出结论，在这些患者中，在所有测试剂量下，静脉内给予LRF脉冲的方式均优于皮下途径。
