Lawrence K E, Wakeford L, Toombs-Ruane L J, MacLachlan C, Pfeffer H, Gibson I R, Benschop J, Riley C B
a School of Veterinary Science , Massey University , Palmerston North , New Zealand.
b New Zealand Veterinary Pathology , Hamilton , New Zealand.
N Z Vet J. 2019 Jul;67(4):180-187. doi: 10.1080/00480169.2019.1605943. Epub 2019 May 6.
To describe the common species and the antimicrobial susceptibility of bacteria cultured from samples submitted to commercial veterinary diagnostic laboratories from beef and pre-production dairy cattle between 2003-2016, and to describe the proportion of isolates with multidrug resistance (MDR). Bacterial culture and antimicrobial susceptibility data from July 2003 to March 2016 were obtained from commercial veterinary diagnostic laboratories in New Zealand. Results were included from samples from beef cattle, irrespective of age or sex, dairy-breed females aged <2 years and dairy-breed males of any age. Submission information provided included the specimen description, the organisms cultured, and the antimicrobial susceptibilities of isolates, if tested. Antimicrobial resistance (AMR) was defined as any isolate not showing susceptibility to an antimicrobial compound and MDR as any isolate showing AMR to ≥3 antimicrobial classes. There were 1,858 unique laboratory submissions, yielding 2,739 isolates. Of these submissions, most were from the Canterbury (389; 21.9%), Manawatu (388; 21.9%) Waikato (231; 12.4%) and Hawke's Bay (136; 7.3%) regions. There were 163 unique species identifications for the 2,739 isolates; the most common were (452; 16.5%), (249; 9.1%), s (230; 8.4%) and serovar Typhimurium (143; 5.2%). Only 251/2,739 (9.2%) isolates from 122/1,858 (6.6%) submissions had antimicrobial susceptibility results. There were no sensitivity results for spp., and only one each for spp., and spp. Amongst the isolates tested, susceptibility to ampicillin was lowest (33/56; 58.9%). Overall, 57/251 (20.7%) isolates tested for antimicrobial susceptibility had MDR, and MDR was most common for spp. (12/17; 71%) and (13/30; 43%). This is the first report on antimicrobial susceptibility and MDR in New Zealand beef and pre-production dairy cattle. Findings highlight the limited use of bacterial culture and sensitivity testing by veterinarians and deficits in the information accompanying submissions. A national antimicrobial resistance surveillance strategy that specifically includes this population is recommended.
描述2003年至2016年间提交给商业兽医诊断实验室的牛肉和产前奶牛样本中培养出的常见细菌种类及其抗菌药敏性，并描述多重耐药（MDR）分离株的比例。2003年7月至2016年3月的细菌培养和抗菌药敏数据来自新西兰的商业兽医诊断实验室。结果包括来自肉牛的样本，无论年龄或性别，年龄小于2岁的奶牛品种雌性和任何年龄的奶牛品种雄性。提供的送检信息包括标本描述、培养的微生物以及分离株的抗菌药敏性（如果进行了检测）。抗菌耐药性（AMR）定义为任何对一种抗菌化合物不敏感的分离株，多重耐药定义为任何对≥3类抗菌药物表现出AMR的分离株。共有1858份独特的实验室送检样本，产生了2739株分离株。在这些送检样本中，大多数来自坎特伯雷地区（389份；21.9%）、马纳瓦图地区（388份；21.9%）、怀卡托地区（231份；12.4%）和霍克斯湾地区（136份；7.3%）。2739株分离株有163种独特的菌种鉴定结果；最常见的是[具体菌种1]（452株；16.5%）、[具体菌种2]（249株；9.1%）、[具体菌种3]（230株；8.4%）和鼠伤寒血清型[具体血清型]（143株；5.2%）。1858份送检样本中的122份（6.6%）的2739株分离株中只有251份（9.2%）有抗菌药敏结果。[具体菌种4]没有药敏结果，[具体菌种5]和[具体菌种6]各只有一份药敏结果。在检测的分离株中，对氨苄西林的敏感性最低（33/56；58.9%）。总体而言，检测抗菌药敏性的251份分离株中有57份（20.7%）有多重耐药，多重耐药在[具体菌种7]（12/17；71%）和[具体菌种8]（13/30；43%）中最为常见。这是关于新西兰牛肉和产前奶牛抗菌药敏性和多重耐药的第一份报告。研究结果突出了兽医对细菌培养和药敏试验的使用有限以及送检样本附带信息的不足。建议制定一项专门包括这一群体的国家抗菌耐药监测战略。
