Fujii Kento, Ota Yuma, Nishiyama Kazuo, Kunitake Hisato, Yamasaki Yumi, Tari Hiroyuki, Araki Kaori, Arakawa Teruaki, Yamasaki Masao
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki.
Faculty of Regional Innovation, University of Miyazaki.
J Oleo Sci. 2019 May 1;68(5):471-479. doi: 10.5650/jos.ess18226. Epub 2019 Apr 9.
Blueberry leaf is currently a popular dietary supplement. Effects of dietary blueberry leaf and its active components on body fat accumulation were examined. C57BL/6J mice were fed high-fat, high-sucrose diet with or without 3% blueberry leaf extract (BLEx) or 3% concentrated-polyphenolic BLEx (CP BLEx) for 8 weeks. Compared to mice fed a high-fat, high-sucrose diet without blueberry leaf, BLEx and CP BLEx significantly reduced body weight and adipose tissue weight gain. Adipocytes were also smaller and and liver lipid accumulatioin was significantly inhibited in mice fed either BLEx or CP BLEx. These effects tended to be more pronounced in mice fed CP BLEx compared to in mice fed BLEx. Together, results suggest that blueberry leaf inhibits body fat accumulation typically observed in mice fed a high-fat, high-sucrose diet, and that inhibition is attributable to polyphenolic components in leaf extracts.
蓝莓叶目前是一种流行的膳食补充剂。研究了膳食蓝莓叶及其活性成分对身体脂肪积累的影响。将C57BL/6J小鼠喂食高脂、高糖饮食8周，饮食中分别添加或不添加3%的蓝莓叶提取物（BLEx）或3%的浓缩多酚蓝莓叶提取物（CP BLEx）。与喂食不含蓝莓叶的高脂、高糖饮食的小鼠相比，BLEx和CP BLEx显著降低了体重和脂肪组织重量增加。在喂食BLEx或CP BLEx的小鼠中，脂肪细胞也更小，肝脏脂质积累受到显著抑制。与喂食BLEx的小鼠相比，这些作用在喂食CP BLEx的小鼠中往往更明显。总之，结果表明蓝莓叶可抑制喂食高脂、高糖饮食的小鼠中通常观察到的身体脂肪积累，且这种抑制作用归因于叶提取物中的多酚成分。
