Mori Masayuki, Higuchi Keiichi
Department of Advanced Medicine for Health Promotion, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University.
Department of Biological Sciences for Intractable Neurological Diseases, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University.
Nihon Yakurigaku Zasshi. 2019;153(4):179-185. doi: 10.1254/fpj.153.179.
Rapid expansion of aged population is predicted worldwide. To cope with problems expected from this situation and extend the period of active and healthy life of people as much as possible, it is important to elucidate not only the biological mechanisms of "aging", but also the etiology of various "age-related diseases". To attain this goal, extensive studies using excellent animal models are indispensable. Senescence-accelerated mouse (SAM) is a series of inbred mouse strains that includes SAMP1, SAMP6, SAMP8, SAMP10, and SAMR1. SAMP strains exhibit accelerated senescence and short lifespan. In addition, each strain shows specific age-related disease phenotypes which are similar to symptoms observed in humans, such as senile amyloidosis (SAMP1), senile osteoporosis (SAMP6), and age-dependent deficits in learning and memory (SAMP8), making SAM mice useful for an aging research. In this review, we introduce the characteristics and application of SAM in geriatrics and aging biology.
预计全球老年人口将迅速增长。为应对这种情况可能出现的问题，并尽可能延长人们积极健康的生活期，不仅阐明“衰老”的生物学机制，而且阐明各种“与年龄相关疾病”的病因很重要。为实现这一目标，使用优秀动物模型进行广泛研究必不可少。衰老加速小鼠（SAM）是一系列近交小鼠品系，包括SAMP1、SAMP6、SAMP8、SAMP10和SAMR1。SAMP品系表现出加速衰老和较短寿命。此外，每个品系都表现出特定的与年龄相关的疾病表型，这些表型与人类观察到的症状相似，如老年淀粉样变性（SAMP1）、老年骨质疏松症（SAMP6）以及学习和记忆方面的年龄依赖性缺陷（SAMP8），这使得SAM小鼠对衰老研究很有用。在本综述中，我们介绍了SAM在老年医学和衰老生物学中的特点及应用。
