对具有与年龄相关的学习和记忆缺陷的衰老加速小鼠（SAM）品系的神经病理学研究。

Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory.

作者信息

Kawamata T, Akiguchi I, Yagi H, Irino M, Sugiyama H, Akiyama H, Shimada A, Takemura M, Ueno M, Kitabayashi T, Ohnishi K, Seriu N, Higuchi K, Hosokawa M, Takeda T

机构信息

Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

出版信息

Exp Gerontol. 1997 Jan-Apr;32(1-2):161-9. doi: 10.1016/s0531-5565(96)00063-0.

DOI:10.1016/s0531-5565(96)00063-0

PMID:9088913

Abstract

In a series of inbred Senescence-Accelerated mice (SAM) strains, accelerated-senescence prone SAMP substrains show early onset and rapid advancement of senescence. SAMP8 and SAMP10, in particular, exhibit a significant age-related deterioration in memory and learning for passive and active avoidance tasks with, respectively, a low and high incidence of systemic senile amyloidosis. In the brains of both SAMP8 and SAMP10 strains, we have found numerous morphological alterations. Here we review the changes seen in both neuronal or glial components in SAMP8/P10 brains. They may serve as markers of the neuronal degeneration leading to the deficits in learning and memory.

摘要

在一系列近交衰老加速小鼠（SAM）品系中，易发生加速衰老的SAMP亚品系表现出衰老的早发和快速进展。特别是SAMP8和SAMP10，在被动和主动回避任务的记忆和学习方面表现出与年龄相关的显著衰退，分别伴有全身性老年淀粉样变性的低发和高发。在SAMP8和SAMP10品系的大脑中，我们发现了许多形态学改变。在此，我们综述SAMP8/P10大脑中神经元或神经胶质成分的变化。它们可能作为导致学习和记忆缺陷的神经元退化的标志物。