State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China.
Int J Oral Sci. 2019 Apr 11;11(2):14. doi: 10.1038/s41368-019-0047-0.
With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK) due to its minimally invasive nature, efficacy, and low risk of systemic side effects and disfigurement. This report presents step-by-step guidelines for applying topical ALA-PDT in the management of OLK based on both the clinical experience of the authors and a systematic review of the current literature. Studies using protocols with standardized parameters and randomized clinical trials at multiple centres with adequate sample sizes and both interim and long-term follow-ups are needed before universally applicable guidelines can be produced in this field.
随着光敏剂和光传输系统的最新发展，局部 5-氨基酮戊酸介导的光动力疗法（ALA-PDT）因其微创性、疗效和低全身副作用及毁容风险，已成为口腔白斑（OLK）治疗的第四种替代治疗方法。本报告根据作者的临床经验和对当前文献的系统评价，为 OLK 的局部 ALA-PDT 管理提供了逐步指南。在这一领域制定普遍适用的指南之前，需要使用具有标准化参数的方案进行研究，并在多个中心进行随机临床试验，样本量充足，并且有中期和长期随访。
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