Binks Daniel, Watson Charles, Puelles Luis
School of Biological Sciences, The University of Western Australia, Perth, WA, Australia.
The Perron Institute for Neurological and Translational Science, Perth, WA, Australia.
Front Neuroanat. 2019 Mar 26;13:34. doi: 10.3389/fnana.2019.00034. eCollection 2019.
The components of the claustrum have been identified by gene expression in mice, but there is still uncertainty about the location of homologous components in primates. To aid interpretation of homologous elements between rodents and primates, we used a current understanding of pallial topology, species-specific telencephalic deformation, and gene expression data. In both rodents and primates, pallial areas maintain conserved topological relationships regardless of relative differences in pallial expansion. The components of the claustrum in primates can, therefore, be identified on the basis of their conserved topological relationships and patterns of gene expression. In rodents, a fairly straight telencephalic long axis runs between the early septopreoptic and amygdalar poles of the pallium. In primates, however, the remarkable dorsal pallial expansion causes this axis to be distorted to form a C shape. This has resulted in a number of errors in the interpretation of the location of claustral components. These errors are likely to have resulted from the unexpected topographical positioning of claustral components due to the bent telencephalic axis. We argue that, once the telencephalic distortion has been accounted for, both rodents and primates have homologous claustral components, and that the topological relationships of these components are conserved regardless of differences in the relative expansion of pallial areas.
小鼠扣带回的组成部分已通过基因表达得以确定，但灵长类动物中同源组成部分的位置仍存在不确定性。为了有助于解释啮齿动物和灵长类动物之间的同源元素，我们利用了当前对大脑皮层拓扑结构、物种特异性端脑变形以及基因表达数据的理解。在啮齿动物和灵长类动物中，无论大脑皮层扩张的相对差异如何，大脑皮层区域都保持着保守的拓扑关系。因此，灵长类动物扣带回的组成部分可以根据其保守的拓扑关系和基因表达模式来确定。在啮齿动物中，一条相当直的端脑长轴在大脑皮层的早期隔前视区和杏仁核极之间延伸。然而，在灵长类动物中，显著的背侧大脑皮层扩张导致这条轴扭曲形成C形。这导致了在扣带回组成部分位置的解释上出现了一些错误。这些错误很可能是由于端脑轴弯曲导致扣带回组成部分意外的地形定位所致。我们认为，一旦考虑到端脑变形，啮齿动物和灵长类动物都有同源的扣带回组成部分，并且无论大脑皮层区域相对扩张的差异如何，这些组成部分的拓扑关系都是保守的。
