Luo Qun, Liu Shengbo, Xie Liming, Yu Yongjie, Zhou Limin, Feng Yuzhen, Cai De
Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Department of Pharmacy, The Central People's Hospital of Zhanjiang, Zhanjiang, China.
Front Pharmacol. 2019 Mar 22;10:195. doi: 10.3389/fphar.2019.00195. eCollection 2019.
Resveratrol (Res) is a multi-functional polyphenol compound that has protective functions in cardiovascular and neurodegenerative diseases. This study aimed to determine the effect of Res on osteogenic differentiation and bone mineralization in zebrafish () with dexamethasone (Dex)-induced bone damage. Our results showed that Dex exposure (15 μmol/l) decreased the green fluorescence areas and the integrated optic density (IOD) values in the skull bones of zebrafish larvae of the TG(SP7:EGFP) strain in a dose-dependent manner ( < 0.01). Furthermore, Dex exposure decreased the alizarin red S-stained areas (bone mineralization area) in the skeleton and spinal bones of zebrafish larvae of the AB strain in a dose-dependent manner ( < 0.01). By contrast, Res treatment (150 μmol/l) significantly increased both the green fluorescence and bone mineralization area in Dex-exposed zebrafish larvae. Thus, our data show that Res improves bone mineralization after glucocorticoid-induced bone damage in a zebrafish model. Res may be a candidate drug for the prevention of osteoporosis.
白藜芦醇（Res）是一种多功能多酚化合物，在心血管疾病和神经退行性疾病中具有保护作用。本研究旨在确定Res对患有地塞米松（Dex）诱导的骨损伤的斑马鱼（）成骨分化和骨矿化的影响。我们的结果表明，暴露于Dex（15 μmol/l）以剂量依赖性方式降低了TG(SP7:EGFP)品系斑马鱼幼体颅骨中的绿色荧光面积和积分光密度（IOD）值（<0.01）。此外，暴露于Dex以剂量依赖性方式降低了AB品系斑马鱼幼体骨骼和脊椎骨中茜素红S染色面积（骨矿化面积）（<0.01）。相比之下，Res处理（150 μmol/l）显著增加了暴露于Dex的斑马鱼幼体中的绿色荧光和骨矿化面积。因此，我们的数据表明，在斑马鱼模型中，Res可改善糖皮质激素诱导的骨损伤后的骨矿化。Res可能是预防骨质疏松症的候选药物。
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