Lee Young Joo, Hong Ji Yun, Kim Seung Chul, Joo Jong Kil, Na Yong Jin, Lee Kyu Sup
Department of Obstetrics and Gynecology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Obstet Gynecol Sci. 2015 Jan;58(1):46-52. doi: 10.5468/ogs.2015.58.1.46. Epub 2015 Jan 16.
The aim of this study is to investigate the association between oxidative stress and bone mineral density (BMD) according to menopausal status of Korean women.
A total of 2,232 women who visited to the health promotion center at Pusan National University Hospital between 2010 and 2014 were included in this cross-sectional study. Laboratory tests, such as uric acid, albumin, total bilirubin, which were evaluated as a natural antioxidants. Homocysteine also was evaluated as a factor associated with oxidative stress. Correlation analyses and partial correlation coefficient between BMD scores and laboratory parameters associated with oxidative stress according to menopausal status were performed with Pearson test.
By correlation analysis, uric acid had only positive correlation with femur and lumbar BMD in premenopausal and postmenopausal group. But albumin and bilirubin, which were the other natural antioxidants, had no correlation with BMD except total bilirubin with femur BMD in postmenopausal group. Homocysteine had negative correlation with femur BMD in postmenopausal group. But there were different results in partial correlation coefficient adjusted by age and BMI. In premenopausal group, uric acid was still positive correlation with femur and lumbar BMD, whereas in postmenopausal group homocysteine had no correlation with femur BMD, total bilirubin and uric acid had no correlation with lumbar BMD. At the multiple logistic regressions, only age and menopause status, uric acid had correlation with BMD.
In this study, homocysteine had no correlation with BMD. But in natural antioxidant, uric acid had only positive correlation with BMD.
本研究旨在根据韩国女性的绝经状态，调查氧化应激与骨矿物质密度（BMD）之间的关联。
本横断面研究纳入了2010年至2014年间到釜山国立大学医院健康促进中心就诊的2232名女性。进行了尿酸、白蛋白、总胆红素等实验室检测，这些被评估为天然抗氧化剂。同型半胱氨酸也被评估为与氧化应激相关的一个因素。采用Pearson检验对绝经状态下BMD评分与氧化应激相关实验室参数之间进行相关性分析和偏相关系数分析。
通过相关性分析，尿酸在绝经前和绝经后组仅与股骨和腰椎BMD呈正相关。但白蛋白和胆红素这两种其他天然抗氧化剂，除绝经后组总胆红素与股骨BMD相关外，与BMD均无相关性。绝经后组同型半胱氨酸与股骨BMD呈负相关。但经年龄和BMI校正后的偏相关系数结果不同。绝经前组中，尿酸仍与股骨和腰椎BMD呈正相关，而绝经后组中同型半胱氨酸与股骨BMD无相关性，总胆红素和尿酸与腰椎BMD无相关性。在多元逻辑回归分析中，只有年龄、绝经状态和尿酸与BMD相关。
在本研究中，同型半胱氨酸与BMD无相关性。但在天然抗氧化剂中，尿酸仅与BMD呈正相关。
