Song Jiayu, Yu Jing, Prayogo Gabriella Wenda, Cao Weidong, Wu Yimei, Jia Zhanjun, Zhang Aihua
Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University Nanjing 210008, China.
Department of Nephrology, Children's Hospital of Nanjing Medical University Nanjing 210008, China.
Am J Transl Res. 2019 Mar 15;11(3):1219-1229. eCollection 2019.
Kidney injury molecule 1 (KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion. It is also named as HAVCR1 (Hepatitis A virus cellular receptor 1) or TIM1 (T-cell immunoglobulin mucin receptor 1), and is expressed in the kidney, liver, and spleen. KIM-1 plays different roles via various molecular targets in immune diseases and kidney injury. KIM-1 is involved in HAV infections, autoimmunity, immune tolerance, and atopic diseases. The urinary KIM-1 level is closely related to its tissue level, and correspondingly related to kidney tissue damage. KIM-1 is not only an early biomarker of acute kidney injury (AKI), but also has a potential role in predicting the long-term renal outcome. In this review, we provide a summary of KIM-1's activities, focusing on the latest studies concerning the important roles of KIM-1 in the immune system and kidney diseases.
肾损伤分子1（KIM-1）是一种I型膜蛋白，由细胞外部分和细胞质部分组成。它也被命名为甲型肝炎病毒细胞受体1（HAVCR1）或T细胞免疫球蛋白粘蛋白受体1（TIM1），在肾脏、肝脏和脾脏中表达。KIM-1通过各种分子靶点在免疫疾病和肾损伤中发挥不同作用。KIM-1参与甲型肝炎病毒感染、自身免疫、免疫耐受和特应性疾病。尿KIM-1水平与其组织水平密切相关，并与肾组织损伤相应相关。KIM-1不仅是急性肾损伤（AKI）的早期生物标志物，而且在预测长期肾脏预后方面也具有潜在作用。在本综述中，我们总结了KIM-1的活性，重点关注有关KIM-1在免疫系统和肾脏疾病中重要作用的最新研究。
