视黄醇棕榈酸酯通过降低氧化应激和抑制细胞凋亡来保护心肌免受缺血/再灌注损伤。
Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis.
作者信息
Tao Luyuan, Huang Kaiyu, Wang Jiaoni, Xue Yangjing, Zhou Yingying, He Fei, Shen Yigen, Wang Jinsheng, Gu Xingjian, Ji Kangting, Qian Lu, Guo Xianyang
机构信息
Department of Cardiology, The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Department of Cardiology, Huangyan Hospital of Wenzhou Medical University Hengjie Road, No. 218, Huangyan, Taizhou 318020, Zhejiang, China.
出版信息
Am J Transl Res. 2019 Mar 15;11(3):1510-1520. eCollection 2019.
Abstract
The purpose of this study was to determine whether retinol palmitate could protect against myocardial ischemia/reperfusion (I/R) injury and explore the underlying mechanism. Retinol palmitate reduced the level of reactive oxygen species and prevented cellular apoptosis. , retinol palmitate increased superoxide dismutase (SOD) activity and reduced the level of malondialdehyde in I/R mice. Retinol palmitate also decreased myocardial infarct size and reduced cellular apoptosis by suppressing the expression of proapoptotic-related proteins and increasing that of SOD-related proteins. Our results suggest that retinol palmitate pretreatment has a protective effect against myocardial I/R injury by maintaining the balance between intracellular oxidants and antioxidants.
摘要
本研究的目的是确定视黄醇棕榈酸酯是否能预防心肌缺血/再灌注（I/R）损伤，并探讨其潜在机制。视黄醇棕榈酸酯降低了活性氧水平并防止细胞凋亡。此外，视黄醇棕榈酸酯增加了超氧化物歧化酶（SOD）活性，并降低了I/R小鼠体内丙二醛的水平。视黄醇棕榈酸酯还通过抑制促凋亡相关蛋白的表达并增加SOD相关蛋白的表达，减小了心肌梗死面积并减少了细胞凋亡。我们的结果表明，视黄醇棕榈酸酯预处理通过维持细胞内氧化剂和抗氧化剂之间的平衡，对心肌I/R损伤具有保护作用。
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