Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Guangdong, China.
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China.
Front Endocrinol (Lausanne). 2024 Jan 12;14:1322474. doi: 10.3389/fendo.2023.1322474. eCollection 2023.
The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways in the heart. These factors collectively heighten the vulnerability of diabetic individuals to myocardial ischemia. Reperfusion therapies have been effectively used in clinical practice. There are limitations to the current clinical methods used to treat myocardial ischemia-reperfusion injury. As a result, reducing post-treatment ischemia/reperfusion injury remains a challenge. Therefore, efforts are underway to provide more efficient therapy. Salvia miltiorrhiza Bunge (Danshen) has been used for centuries in ancient China to treat cardiovascular diseases (CVD) with rare side effects. Salvianolic acid is a water-soluble phenolic compound with potent antioxidant properties and has the greatest hydrophilic property in Danshen. It has recently been discovered that salvianolic acids A (SAA) and B (SAB) are capable of inhibiting apoptosis by targeting the JNK/Akt pathway and the NF-κB pathway, respectively. This review delves into the most recent discoveries regarding the therapeutic and cardioprotective benefits of salvianolic acid for individuals with diabetes. Salvianolic acid shows great potential in myocardial protection in diabetes mellitus. A thorough understanding of the protective mechanism of salvianolic acid could expand its potential uses in developing medicines for treating diabetes mellitus related myocardial ischemia-reperfusion.
现代城市中糖尿病的发病率和相关死亡率逐年上升。此外，升高的葡萄糖水平会导致活性氧（ROS）、铁死亡和心脏保护途径的破坏增加。这些因素共同增加了糖尿病患者心肌缺血的易感性。再灌注治疗已在临床实践中得到有效应用。目前用于治疗心肌缺血再灌注损伤的临床方法存在局限性。因此，减少治疗后的缺血/再灌注损伤仍然是一个挑战。因此，正在努力提供更有效的治疗方法。丹参在中国古代已有数百年的历史，用于治疗心血管疾病（CVD），副作用罕见。丹酚酸是一种具有强大抗氧化特性的水溶性酚类化合物，在丹参中具有最大的亲水性。最近发现丹酚酸 A（SAA）和丹酚酸 B（SAB）能够通过靶向 JNK/Akt 途径和 NF-κB 途径分别抑制细胞凋亡。本综述深入探讨了丹酚酸在糖尿病个体中的治疗和心脏保护作用的最新发现。丹酚酸在糖尿病中的心肌保护中具有很大的潜力。深入了解丹酚酸的保护机制可能会扩大其在开发治疗糖尿病相关心肌缺血再灌注药物方面的潜在用途。
