长链非编码RNA LINC00341通过miR-214/FOXO4反馈环促进血管平滑肌细胞增殖和迁移。
Long noncoding RNA LINC00341 promotes the vascular smooth muscle cells proliferation and migration via miR-214/FOXO4 feedback loop.
作者信息
Liu Xiu, Ma Bing-Dong, Liu Shan, Liu Ju, Ma Bao-Xin
机构信息
Department of Cardiology, Yantai Affiliated Hospital of Binzhou Medical University Yantai, Shandong, China.
Department of Hand Microsurgery, Affiliated Hospital of Binzhou Medical University Binzhou, Shandong, China.
出版信息
Am J Transl Res. 2019 Mar 15;11(3):1835-1842. eCollection 2019.
Abstract
Increasing evidences have indicated the vital roles of long noncoding RNA (lncRNA) in the atherosclerosis. However, whether lncRNA LINC00341 play pivotal roles in the vascular smooth muscle cells (VSMCs) is still unclear. This work presents the authentic functions of LINC00341 on the proliferation and migration of VSMCs and unveils the underlying mechanism. Functional experiment data demonstrated that LINC00341 expression was increased in the ox-LDL induced VSMCs with dose-dependent and time-dependent mode. Moreover, the knockdown of LINC00341 suppressed the proliferation and migration ability of VSMCs. Mechanically, we found that LINC00341 promoted the FOXO4 protein expression via sponging miR-214, which, in return, resulting in the transcription activation of LINC00341. In conclusion, the results conclude that LINC00341 promotes the proliferation and migration of VSMCs and confirm the positive feedback loop of LINC00341/miR-214/FOXO4 axis.
摘要
越来越多的证据表明长链非编码RNA（lncRNA）在动脉粥样硬化中发挥着重要作用。然而，lncRNA LINC00341是否在血管平滑肌细胞（VSMC）中起关键作用仍不清楚。这项工作揭示了LINC00341对VSMC增殖和迁移的真实功能，并揭示了其潜在机制。功能实验数据表明，在氧化低密度脂蛋白诱导的VSMC中，LINC00341的表达呈剂量依赖性和时间依赖性增加。此外，敲低LINC00341可抑制VSMC的增殖和迁移能力。从机制上讲，我们发现LINC00341通过吸附miR-214促进FOXO4蛋白表达，反过来，这又导致LINC00341的转录激活。总之，结果表明LINC00341促进VSMC的增殖和迁移，并证实了LINC00341/miR-214/FOXO4轴的正反馈环。
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