Department of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China 410011.
The Institute of Vascular Diseases, Central South University, Changsha, Hunan, China 410011.
Biomed Res Int. 2021 Jul 27;2021:9935671. doi: 10.1155/2021/9935671. eCollection 2021.
Endovascular repair including percutaneous transluminal angioplasty (PTA) and stent implantation has become the standard approach for the treatment of peripheral arterial disease; however, restenosis is still the main limited complication for the long-term success of the endovascular repair. Endothelial denudation and regeneration, inflammatory response, and neointimal hyperplasia are major pathological processes occurring during in-stent restenosis (ISR). MicroRNAs exhibit great potential in regulating several vascular biological events in different cell types and have been identified as novel therapeutic targets as well as biomarkers for ISR prevention. This review summarized recent experimental and clinical studies on the role of miRNAs in ISR modification, with the aim of unraveling the underlying mechanism and potential therapeutic strategy of ISR.
血管内修复术包括经皮腔内血管成形术（PTA）和支架植入术，已成为外周动脉疾病治疗的标准方法；然而，再狭窄仍然是血管内修复长期成功的主要受限并发症。血管内支架再狭窄（ISR）过程中，内皮细胞剥脱和再生、炎症反应和新生内膜增生是主要的病理过程。microRNAs 在调节不同细胞类型中的几种血管生物学事件方面具有巨大的潜力，已被确定为 ISR 预防的新型治疗靶点和生物标志物。本综述总结了最近关于 microRNAs 在 ISR 修饰中的作用的实验和临床研究，旨在揭示 ISR 的潜在机制和潜在治疗策略。
