Tang Lingyun, Zhang Wenjie, Qi Teng, Jiang Zhengting, Tang Dong
Clinical Medical College, Yangzhou University, Yangzhou, 225000, China.
School of Medicine, Chongqing University, Chongqing, 400030, China.
Cell Commun Signal. 2025 Feb 13;23(1):82. doi: 10.1186/s12964-024-02009-7.
Gastric cancer (GC) is a common and frequent malignant cancer of the digestive system with a poor prognosis. In addition to common therapies such as surgical resection and chemotherapy, novel biological interventions are quite valuable for research. Exosomes are extracellular vesicles (EVs) that originate from various cell types and contain proteins, RNA, DNA, and other components that transmit biological signals and mediate intercellular communication. Numerous studies have shown that exosomes shape the tumor microenvironment (TME) by affecting hypoxia, inflammation, immunity, metabolism, and interstitial changes in the tumor, playing a crucial role in the development and metastasis of GC. This article reviews the important role of exosomes in the TME of GC and explores their potential clinical applications in GC treatment.
胃癌（GC）是消化系统常见且频发的恶性肿瘤，预后较差。除手术切除和化疗等常规治疗外，新型生物干预措施在研究中具有重要价值。外泌体是源自多种细胞类型的细胞外囊泡（EVs），包含蛋白质、RNA、DNA和其他传递生物信号并介导细胞间通讯的成分。大量研究表明，外泌体通过影响肿瘤中的缺氧、炎症、免疫、代谢和间质变化来塑造肿瘤微环境（TME），在胃癌的发生和转移中起关键作用。本文综述了外泌体在胃癌肿瘤微环境中的重要作用，并探讨了它们在胃癌治疗中的潜在临床应用。
