Tuzzio Leah, Larson Eric B
Kaiser Permanente Washington Health Research Institute, US.
EGEMS (Wash DC). 2019 Apr 3;7(1):10. doi: 10.5334/egems.285.
This commentary describes the need for a different context to clinical research that could speed the discovery and implementation of evidence-based advancements to health care delivery. Pragmatic clinical trials (PCTs) are a promising type of trial conducted within real-world health care delivery systems like organizations within the Health Care Systems Research Network, that embrace research as part of their culture of continuous learning and improvement. In these learning health systems (LHSs) clinical practice influences research and vice versa. A goal of LHSs is to operationalize evidence generated by research, particularly PCTs, into improvements that are sustained after a trial ends. PCTs that demonstrate value to health systems and foster implementation could reduce delays in translating research into practice.
本评论描述了临床研究需要一个不同的背景，这可能会加速基于证据的医疗保健进步的发现和实施。实用临床试验（PCT）是一种很有前景的试验类型，在诸如医疗保健系统研究网络中的组织等现实世界的医疗保健提供系统内进行，这些组织将研究作为其持续学习和改进文化的一部分。在这些学习型健康系统（LHS）中，临床实践影响研究，反之亦然。LHS的一个目标是将研究产生的证据，特别是PCT产生的证据，转化为试验结束后仍能持续的改进。对健康系统有价值并促进实施的PCT可以减少将研究转化为实践的延迟。
