Institute of Physiology Active Compounds, Russian Academy of Sciences, 1 Severnyj Proezd, Chernogolovka, Russian Federation.
Cardiff University, Life Sciences Building, Museum Avenue, Cardiff, Wales, CF10 3AX, UK.
Hum Cell. 2019 Jul;32(3):223-230. doi: 10.1007/s13577-019-00251-7. Epub 2019 Apr 10.
Recent studies have demonstrated that breast milk contains a population of cells displaying many of the properties typical of stem cells. This review outlines progress made in this newly emerging field of stem cell biology and provides an analysis of the available data on purification, propagation and differentiation of certain types of progenitor cells from breast milk. The possible fates of breast milk cells, including microchimerism caused by their transmission to the distant organs of the infant, are also discussed. Unique properties of breast milk-derived stem cells, such as their unusually low tumorigenic potential and their negligible ability to form teratomas, are highlighted as obvious advantages for using these cells in regenerative therapy.
最近的研究表明,母乳中含有一群细胞,这些细胞表现出许多干细胞的典型特性。这篇综述概述了这一新兴的干细胞生物学领域的进展,并对从母乳中分离、增殖和分化某些类型祖细胞的现有数据进行了分析。还讨论了母乳细胞的可能命运,包括通过它们传播到婴儿的远处器官而引起的微嵌合体现象。强调了母乳来源的干细胞的独特特性,如其异常低的致瘤潜力和几乎不能形成畸胎瘤的能力,这是将这些细胞用于再生治疗的明显优势。