Ryan Michael P, Woolridge Katelyn F, Sedrak Michael, Berlingeri-Ramos Alma C, Group Ashley R
School of Medicine, University of Texas Medical Branch, Galveston, Texas.
Department of Dermatology, University of Texas Medical Branch, Galveston, Texas.
J Cutan Pathol. 2019 Jul;46(7):546-549. doi: 10.1111/cup.13474. Epub 2019 May 1.
Extraskeletal osteosarcoma (ESOS) is a rare variant of osteosarcoma that arises without attachment to the underlying skeleton. These cancers are typically found embedded in deeper tissues, most commonly the muscle or fascia, and are rarely found within the skin or subcutis. Most tumors are large in size upon initial presentation, and carry a poor prognosis. We discuss the case of a 48-year-old Caucasian woman who presented to a dermatology clinic with an asymptomatic, small, mobile, subcutaneous mass that appeared clinically benign. After elective removal and histopathologic examination, the patient was diagnosed with ESOS. ESOS presenting in this manner is exceedingly rare, and this case highlights the importance of sending all excised specimens, even those with a benign presentation, for pathologic examination.
骨外骨肉瘤（ESOS）是骨肉瘤的一种罕见变体，其发生时不附着于下方骨骼。这些癌症通常见于深部组织内，最常见于肌肉或筋膜，很少见于皮肤或皮下组织。大多数肿瘤初诊时体积较大，预后较差。我们讨论了一名48岁白种女性的病例，该患者因无症状、小的、可移动的皮下肿物就诊于皮肤科诊所，临床检查显示肿物为良性。经择期切除及组织病理学检查后，患者被诊断为骨外骨肉瘤。以这种方式出现的骨外骨肉瘤极为罕见，该病例凸显了将所有切除标本（即使是临床表现为良性的标本）送检病理检查的重要性。
