Radko Lidia, Cybulski Wojciech
a Department of Pharmacology and Toxicology , National Veterinary Research Institute , Pulawy , Poland.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 May;36(5):722-728. doi: 10.1080/19440049.2019.1584406. Epub 2019 Apr 11.
Widespread use of coccidiostats, in spite of beneficial control of protozoan infections in poultry, implies a risk of residues in edible tissues, and there is increasing interest in the development of strategies for prevention of veterinary drugs residue in food-producing animals. The aim of this study is assigned to clarify the impact of silymarin addendum in the diet on lasalocid concentration in the liver and breast muscles from the broiler. Four groups of chickens received a feed with lasalocid at levels between 75 and 200 mg kg. Other four groups received a feed with lasalocid (75-200 mg kg) plus silymarin. Significant differences of lasalocid concentrations between the liver and breast muscles were observed. Moreover, the chickens from the groups supplemented with silymarin shown significant decreases of lasalocid concentrations in the analysed tissues. The herbal substance did not counteract the ionophore in the treatment of coccidiosis and did not change biochemical parameters of blood. These findings suggest that silymarin might be used in chicken feeding in order to reduce the risk from lasalocid contamination of the broiler edible tissues.
尽管抗球虫药在控制家禽原生动物感染方面有有益作用，但广泛使用意味着可食用组织中存在残留风险，并且人们对制定预防食用动物兽药残留的策略越来越感兴趣。本研究的目的是阐明日粮中添加水飞蓟宾对肉鸡肝脏和胸肌中拉沙洛西浓度的影响。四组鸡接受了含有75至200毫克/千克拉沙洛西的饲料。其他四组接受了含有拉沙洛西（75 - 200毫克/千克）加水飞蓟宾的饲料。观察到肝脏和胸肌中拉沙洛西浓度存在显著差异。此外，添加水飞蓟宾组的鸡在所分析组织中的拉沙洛西浓度显著降低。这种草药物质在治疗球虫病时没有抵消离子载体的作用，也没有改变血液的生化参数。这些发现表明，水飞蓟宾可用于鸡的饲养，以降低肉鸡可食用组织受拉沙洛西污染的风险。
