Kennedy D G, Hughes P J, Blanchflower W J
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast, UK.
Food Addit Contam. 1998 Jul;15(5):535-41. doi: 10.1080/02652039809374678.
Monensin, salinomycin and narasin were detectable in six, two and one, respectively, out of 161 eggs surveyed in Northern Ireland in 1994. In all cases, the concentrations detected were less than 2.5 ng/g. Lasalocid was detectable in 107 eggs at concentrations ranging from 0.3 to 129 ng/g. Cross-contamination of unmedicated feeds with monensin during feed manufacture (up to eight batches of unmedicated feed contaminated with monensin) was similar to that previously observed for lasalocid (up to nine batches contaminated). Therefore differences in the incidence in eggs could not be explained by differential carry-over during feed manufacture. In a feeding trial it was shown that the relative ability of monensin, salinomycin and lasalocid to accumulate in eggs was in the ratio 0.12:3.3:63 ng/g egg per mg/kg feed, respectively. This indicated that the potential for monensin and salinomycin to cause residues in eggs was very low, by comparison with lasalocid. In 1995, a granular formulation of the lasalocid premix was introduced into the United Kingdom that decreased the carry-over of this drug from medicated to unmedicated feed. Six months after the introduction of this formulation, the incidence of lasalocid residues in eggs (21%) was lower than that found (66.5%) in an earlier survey (1994) carried out, and published, by this laboratory.
1994年在北爱尔兰检测的161枚鸡蛋中，分别有6枚、2枚和1枚检测出莫能菌素、盐霉素和那拉菌素。在所有情况下，检测到的浓度均低于2.5纳克/克。107枚鸡蛋中检测到拉沙洛西，浓度范围为0.3至129纳克/克。饲料生产过程中未加药饲料被莫能菌素交叉污染（多达八批未加药饲料被莫能菌素污染）的情况与之前观察到的拉沙洛西污染情况（多达九批被污染）相似。因此，鸡蛋中发生率的差异无法用饲料生产过程中的不同残留来解释。在一项饲养试验中表明，莫能菌素、盐霉素和拉沙洛西在鸡蛋中积累的相对能力分别为每毫克/千克饲料0.12:3.3:63纳克/克鸡蛋。这表明，与拉沙洛西相比，莫能菌素和盐霉素在鸡蛋中产生残留的可能性非常低。1995年，一种拉沙洛西预混剂的颗粒制剂被引入英国，这降低了这种药物从加药饲料到未加药饲料的残留。引入这种制剂六个月后，鸡蛋中拉沙洛西残留的发生率（21%）低于本实验室早些时候（1994年）进行并发表的一项调查中发现的发生率（66.5%）。
