Departments of Hematology.
Departments of Pathology.
Appl Immunohistochem Mol Morphol. 2020 Nov/Dec;28(10):e94-e98. doi: 10.1097/PAI.0000000000000769.
We report 2 cases of composite lymphoma comprising mantle cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, a rare association that has only been reported twice in the literature. In case 1, a 64-year-old woman presented with massive splenomegaly and lymphadenopathy. Immunohistochemical studies of the lymph node biopsy suggested the presence of 2 lymphomas, a predominant component of a peripheral T-cell lymphoma, not otherwise specified and an in situ mantle cell neoplasia. These suspicions were confirmed with polymerase chain reaction and fluorescence in situ hybridization studies. In case 2, a 45-year-old man presented with an enlarged right tonsil. Contrary to case 1, the biopsy suggested a predominant infiltration of a classical mantle cell lymphoma and an atypical proliferation of T cells. Biclonality was also confirmed with fluorescence in situ hybridization and molecular techniques. Both cases were treated with an up-front autologous stem cell transplantation after achieving first complete remission, and they remained free of disease for a long period of time.
我们报告了 2 例包含套细胞淋巴瘤和外周 T 细胞淋巴瘤，非特指型的复合淋巴瘤，这种罕见的关联在文献中仅报道过 2 次。在病例 1 中，一位 64 岁女性因巨脾和淋巴结病就诊。淋巴结活检的免疫组化研究提示存在 2 种淋巴瘤，一种是主要的外周 T 细胞淋巴瘤，非特指型，另一种是原位套细胞肿瘤。这些怀疑通过聚合酶链反应和荧光原位杂交研究得到了证实。在病例 2 中，一位 45 岁男性因右扁桃体肿大就诊。与病例 1 不同，活检提示主要浸润性经典套细胞淋巴瘤和 T 细胞不典型增生。荧光原位杂交和分子技术也证实了双克隆性。这两个病例在首次完全缓解后均接受了一线自体干细胞移植治疗，并且在很长一段时间内都没有疾病复发。
