Departments of Anesthesiology, Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, California, USA.
Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, P.R. China.
Curr Opin Cardiol. 2019 May;34(3):260-269. doi: 10.1097/HCO.0000000000000616.
Characterized by enlarged ventricle and loss of systolic function, dilated cardiomyopathy (DCM) has the highest morbidity among all the cardiomyopathies. Although it is well established that DCM is typically caused by mutations in a large number of genes, there is an emerging appreciation for the contribution of epigenetic alteration in the development of DCM.
We present some of the recent progress in the field of epigenetics in DCM by focusing on the four major epigenetic modifications, that is, DNA methylation, histone modification, chromatin remodeling as well as the noncoding RNAs. The major players involved in these DCM-related epigenetic reprogramming will be highlighted. Finally, the diagnostic and the therapeutic implications for DCM based on new knowledge of epigenetic regulation will also be discussed.
As a rapidly expanding field, epigenetic studies in DCM have the promise to yield both novel mechanistic insights as well as potential new avenues for more effective treatment of the disease.
扩张型心肌病（DCM）以心室扩张和收缩功能丧失为特征，是所有心肌病中发病率最高的。尽管人们已经充分认识到 DCM 通常是由大量基因突变引起的，但人们越来越认识到表观遗传改变在 DCM 发病机制中的作用。
我们通过关注四种主要的表观遗传修饰，即 DNA 甲基化、组蛋白修饰、染色质重塑以及非编码 RNA，介绍了 DCM 领域中表观遗传学的一些最新进展。将重点介绍涉及这些与 DCM 相关的表观遗传重编程的主要参与者。最后，还将讨论基于表观遗传调控新知识的 DCM 的诊断和治疗意义。
作为一个快速发展的领域，DCM 的表观遗传学研究有望提供新的机制见解，并为更有效地治疗该疾病提供新的途径。
