Daggumilli Satyasudha, Vanathi Murugesan, Ganger Anita, Goyal Vinay, Tandon Radhika
Cornea & Ocular Surface Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Cardiology & Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
Cornea. 2019 Sep;38(9):1131-1136. doi: 10.1097/ICO.0000000000001951.
To evaluate the progression of corneal endothelial changes in patients with Parkinson disease (PD) on long-term oral amantadine therapy.
A prospective comparative longitudinal observational study of 90 patients (180 eyes) with PD on more than 6 months of oral amantadine therapy, 30 amantadine naive patients with PD, and 30 healthy controls (age and gender matched). Corneal endothelial cell parameters (endothelial cell density, percentage hexagonality of the cells, and coefficient of variation) and corneal subbasal nerve fiber layer changes were studied over a follow-up period of 1 year.
The amantadine patients with PD group had a statistically significant decrease in endothelial cell density (1.51% vs. 0.94% vs. 0.55%) (P = 0.04), decrease of percentage hexagonality of the cells (4.98% vs. 3.56% vs. 2.31%) (P = 0.01), and increase of coefficient of variation (6.12% vs. 4.80% vs. 3.30%) (P = 0.03) compared with amantadine naive patients with PD and controls, respectively. Analysis of changes in the patients with PD based on the daily dosage of amantadine showed greater change in endothelial parameters in patients who were on 400 mg amantadine.
Long-term amantadine therapy seems to effect changes on corneal endothelium.
评估长期口服金刚烷胺治疗的帕金森病（PD）患者角膜内皮变化的进展情况。
对90例（180只眼）接受口服金刚烷胺治疗超过6个月的PD患者、30例未服用过金刚烷胺的PD患者和30例健康对照者（年龄和性别匹配）进行前瞻性比较纵向观察研究。在1年的随访期内研究角膜内皮细胞参数（内皮细胞密度、细胞六边形百分比和变异系数）以及角膜基底膜下神经纤维层的变化。
与未服用金刚烷胺的PD患者和对照组相比，服用金刚烷胺的PD患者组内皮细胞密度有统计学意义的下降（分别为1.51%对0.94%对0.55%）（P = 0.04），细胞六边形百分比下降（4.98%对3.56%对2.31%）（P = 0.01），变异系数增加（6.12%对4.80%对3.30%）（P = 0.03）。根据金刚烷胺日剂量对PD患者变化进行分析显示，服用400 mg金刚烷胺的患者内皮参数变化更大。
长期金刚烷胺治疗似乎会对角膜内皮产生影响。
