Department of Ophthalmology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.
Ophthalmology. 2010 Jun;117(6):1214-9. doi: 10.1016/j.ophtha.2009.10.039. Epub 2010 Feb 13.
To evaluate the effect of amantadine on corneal endothelial cells in subjects with Parkinson's disease.
Cross-sectional study.
A total of 169 subjects (169 eyes) taking amantadine orally for Parkinson's disease and the same number of age- and gender-matched controls.
Endothelial indices were compared between the amantadine-treated and age-matched control groups. The amantadine-treated group was divided into 3 subgroups according to the cumulative dose and duration of treatment. Endothelial changes were compared between the amantadine group and the normal control group, and among subgroups.
Slit-lamp biomicroscopy, central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation, and hexagonality.
The amantadine group had significantly lower ECD (mean +/- standard error; 2662.47+/-29.06 vs. 2784.72+/-25.89, P = 0.002), lower hexagonality (56.94+/-1.07 vs. 60.97+/-0.87, P = 0.004), and greater coefficient of variation (35.59+/-0.57 vs. 32.66+/-0.52, P = 0.000) compared with the age-matched control group. Longer duration and higher cumulative dose amantadine therapy led to a greater reduction in ECD (P<0.05) compared with the normal age-matched control group.
Amantadine is more likely to have an effect on corneal endothelial cells in a dose-dependent manner when used long-term.
评估金刚烷胺对帕金森病患者角膜内皮细胞的影响。
横断面研究。
共 169 例（169 只眼）长期口服金刚烷胺治疗帕金森病的患者，以及年龄和性别相匹配的对照组。
比较金刚烷胺治疗组和年龄匹配对照组之间的内皮指数。根据累积剂量和治疗持续时间，将金刚烷胺治疗组分为 3 个亚组。比较金刚烷胺组与正常对照组以及亚组之间的内皮变化。
裂隙灯显微镜、中央角膜厚度（CCT）、内皮细胞密度（ECD）、变异系数和六边形。
与年龄匹配对照组相比，金刚烷胺组 ECD（均数+标准误；2662.47+/-29.06 对 2784.72+/-25.89，P=0.002）、六边形（56.94+/-1.07 对 60.97+/-0.87，P=0.004）和变异系数（35.59+/-0.57 对 32.66+/-0.52，P=0.000）均显著降低。与正常年龄匹配对照组相比，金刚烷胺治疗时间较长和累积剂量较高导致 ECD 降低更为明显（P<0.05）。
长期应用金刚烷胺可能会出现剂量依赖性的角膜内皮细胞损伤。
