Department of Pathology, Anhui Medical University, Hefei, China.
Laboratory of Pathogenic Microbiology and Immunology, Anhui Medical University, Hefei, China.
FEBS Open Bio. 2019 Jun;9(6):1097-1108. doi: 10.1002/2211-5463.12639. Epub 2019 Apr 29.
Coronin-like actin-binding protein 1C (CORO1C) is a member of the WD repeat protein family that regulates actin-dependent processes by assembling F-actin. CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma. Here, we investigated the role of CORO1C in gastric cancer. Higher expression levels of CORO1C were detected in gastric cancer tissues as compared with normal gastric tissues. In addition, CORO1C levels were found to be positively correlated with lymph node metastasis in gastric cancer patients. The expression levels of CORO1C were higher in stage III-IV gastric cancer patients (80.8%) than in stage I-II gastric cancer patients(57.1%). Gastric cancer patients positive for CORO1C expression showed lower relapse-free survival and overall survival rates. Knockdown of CORO1C dramatically suppressed total cell number, cell viability, cell colony formation, cell mitosis and cell metastasis, and promoted apoptosis of gastric cancer cells. Furthermore, cyclin D1 and vimentin were found to be positively regulated by CORO1C. As cyclin D1 and vimentin play an oncogenic role in gastric cancer, CORO1C may exert its tumor-promoting activity through these proteins.
卷曲螺旋结构域蛋白 1C（CORO1C）是 WD 重复蛋白家族的成员，通过组装 F-肌动蛋白来调节肌动蛋白依赖性过程。先前有报道称 CORO1C 可促进乳腺癌和肺鳞癌的转移。在这里，我们研究了 CORO1C 在胃癌中的作用。与正常胃组织相比，胃癌组织中检测到 CORO1C 的表达水平更高。此外，CORO1C 水平与胃癌患者的淋巴结转移呈正相关。在 III-IV 期胃癌患者（80.8%）中 CORO1C 的表达水平高于 I-II 期胃癌患者（57.1%）。CORO1C 表达阳性的胃癌患者的无复发生存率和总生存率较低。CORO1C 的敲低显著抑制了胃癌细胞的总细胞数、细胞活力、细胞集落形成、细胞有丝分裂和细胞转移，并促进了细胞凋亡。此外，发现 CORO1C 可正向调节细胞周期蛋白 D1 和波形蛋白。由于细胞周期蛋白 D1 和波形蛋白在胃癌中发挥致癌作用，因此 CORO1C 可能通过这些蛋白发挥其促进肿瘤的活性。
