补体锁定病毒以阻止感染。

Complement Seals a Virus to Block Infection.

机构信息

Department of Microbiology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.

Department of Immunology and Microbiology, The Scripps Research Institute, 10660 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Cell Host Microbe. 2019 Apr 10;25(4):482-483. doi: 10.1016/j.chom.2019.03.010.

DOI:10.1016/j.chom.2019.03.010

PMID:30974082

Abstract

In this issue of Cell Host & Microbe, Bottermann et al. (2019) reveal that complement component C4 inhibits adenovirus by inactivating the virus capsid through mechanisms requiring antibody engagement, but not late-acting complement pathways. This antiviral function likely broadly impacts non-enveloped viruses and may help illuminate the process of virus disassembly.

摘要

在本期《细胞宿主与微生物》中，Bottermann 等人（2019 年）揭示了补体成分 C4 通过需要抗体结合的机制来使病毒衣壳失活，从而抑制腺病毒，但不依赖晚期补体途径。这种抗病毒功能可能广泛影响无包膜病毒，并有助于阐明病毒解体的过程。