Provincial Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Department of Geriatric Medicine, Fujian Provincial Hospital, Fuzhou, Fujian China.
Horm Metab Res. 2019 Jun;51(6):367-374. doi: 10.1055/a-0882-7382. Epub 2019 Apr 11.
An elevated serum uric acid (SUA) level is closely associated with increased arterial stiffness. However, whether this association is independent of conventional cardiovascular risk factors is controversial. This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular risk factors. In female subjects with more than two cardiovascular risk factors, compared with the first quartile of SUA, higher SUA quartiles were associated with a higher probability of increased baPWV (OR=1.500, 1.478, 1.774 for SUA Q2-Q4). In further stratified association analysis, compared with Q1, SUA quartiles showed a graded association with increased baPWV in subjects with TC≥5.2 mmol/l (OR=1.758, 1.942, 2.354 for Q2, Q3, and Q4 respectively), LDL-C≥3.3 mmol/l (OR=1.510, 2.255 for Q3 and Q4) and FBG≥7.0 mmol/l (OR=1.516, 1.748 for Q3 and Q4). In the Chinese coastal female population, the association of high SUA and increased arterial stiffness is dependent on the coexistence of at least one cardiovascular risk factor, especially hypercholesterolemia.
血尿酸（SUA）水平升高与动脉僵硬度增加密切相关。然而，这种关联是否独立于传统心血管危险因素仍存在争议。本研究旨在探讨 SUA 是否与肱踝脉搏波速度（baPWV）评估的动脉僵硬度独立相关，以及这种关联在多大程度上依赖于心血管危险因素。动脉僵硬度增加定义为 baPWV＞1400cm/s。心血管危险因素定义为高血压、糖尿病、血脂异常和 BMI≥24.0kg/m。共纳入 3342 名受试者（男性 1334 名，女性 2008 名，平均年龄 53.79±13.18 岁）。SUA 水平随心血管危险因素数量的增加呈梯度升高。在女性受试者中，有两个以上心血管危险因素的情况下，与 SUA 第一四分位相比，SUA 较高四分位与较高的 baPWV 增加概率相关（SUA Q2-Q4 的 OR 值分别为 1.500、1.478、1.774）。在进一步的分层关联分析中，与 Q1 相比，SUA 四分位与 TC≥5.2mmol/l（Q2、Q3、Q4 的 OR 值分别为 1.758、1.942、2.354）、LDL-C≥3.3mmol/l（Q3 和 Q4 的 OR 值分别为 1.510、2.255）和 FBG≥7.0mmol/l（Q3 和 Q4 的 OR 值分别为 1.516、1.748）的受试者中，SUA 与 baPWV 增加呈梯度相关。在中国沿海女性人群中，SUA 升高与动脉僵硬度增加的关联取决于至少存在一种心血管危险因素，尤其是高胆固醇血症。
