Department of Epidemiology-Data-Biostatistics, Delegation of Clinical Research and Innovation (DRCI), Foch hospital, Suresnes, France.
J Clin Hypertens (Greenwich). 2022 Jul;24(7):885-897. doi: 10.1111/jch.14527. Epub 2022 Jun 24.
Arterial stiffness (AS), measured by arterial stiffness index (ASI), is a determinant in cardiovascular (CV) diseases. A high serum uric acid (SUA) level is a known risk factor for CV disease. The authors investigated the relationship between SUA and ASI in the middle-age UK Biobank population study. AS was defined as ASI > 10 m/s. A cross-sectional study was conducted from 126 663 participants. Participants were divided into four quartiles according to SUA levels and sex. Sex multivariate analyses were performed with adjustment for confounding factors. The average ASI for overall participants was 9.3 m/s (SD: 2.9); 9.9 m/s (SD: 2.8) for men and 8.7 m/s (SD: 2.9) for women (P < .001). Men presented higher SUA rate (351.3 mmol/L (SD:67.9)) than women (270.7 mmol/L (SD:64.4)), P < .001. In men multivariate analysis, SUA remained a determinant of AS, with an increase in the strength of the association between the quartiles, Q4 versus Q1, OR = 1.10 [1.05-1.16], P < .001, Q3 versus Q1, OR = 1.09 [1.04-1.14], P < .001 but not between Q2 and Q1 (P = .136). In women, SUA remained significant for AS, with an increase in the strength of the association between the quartiles, Q4 versus Q1, OR = 1.22 [1.15-1.30], P < .001, Q3 versus Q1, OR = 1.13 [1.07-1.19], P < .001 and no difference between Q2 and Q1 (P = .101). When applying continuous SUA values in the multivariate analysis, SUA remained significant (P < .001), with a Youden index value for men = 338.3 mmol/L and for women = 267.3 mmol/L. High SUA levels were associated with AS, suggesting that SUA could be used as a predictor of atherosclerosis.
动脉僵硬度（AS），通过动脉僵硬度指数（ASI）来测量，是心血管疾病（CV）的决定因素。血清尿酸（SUA）水平升高是 CV 疾病的已知危险因素。作者研究了中年 UK Biobank 人群研究中 SUA 与 ASI 之间的关系。AS 定义为 ASI＞10m/s。对来自 12663 名参与者的横断面研究进行了分析。根据 SUA 水平和性别将参与者分为四组。进行了男女多变量分析，并调整了混杂因素。总体参与者的平均 ASI 为 9.3m/s（SD：2.9）；男性为 9.9m/s（SD：2.8），女性为 8.7m/s（SD：2.9）（P＜0.001）。男性的 SUA 发生率（351.3mmol/L（SD：67.9））高于女性（270.7mmol/L（SD：64.4）），P＜0.001。在男性多变量分析中，SUA 仍然是 AS 的决定因素，随着 quartiles 之间关联强度的增加，Q4 与 Q1 相比，OR=1.10[1.05-1.16]，P＜0.001，Q3 与 Q1 相比，OR=1.09[1.04-1.14]，P＜0.001，但 Q2 与 Q1 之间没有差异（P=0.136）。在女性中，SUA 仍然与 AS 显著相关，随着 quartiles 之间关联强度的增加，Q4 与 Q1 相比，OR=1.22[1.15-1.30]，P＜0.001，Q3 与 Q1 相比，OR=1.13[1.07-1.19]，P＜0.001，而 Q2 与 Q1 之间没有差异（P=0.101）。当在多变量分析中应用连续的 SUA 值时，SUA 仍然具有统计学意义（P＜0.001），男性的 Youden 指数值为 338.3mmol/L，女性为 267.3mmol/L。高 SUA 水平与 AS 相关，提示 SUA 可用作动脉粥样硬化的预测因子。
