Association of rs699947 (-2578 C/A) and rs2010963 (-634 G/C) Single Nucleotide Polymorphisms of the Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case-Control Study.

BACKGROUND

Two single nucleotide polymorphisms (SNPs) of the gene, rs699947 and rs2010963, are responsible for differentiated gene expression. A mutual dependence between VEGF and leptin serum level has been observed. This study investigated the associations between the rs699947 and rs2010963 SNPs of gene, VEGF-A, and leptin serum concentrations, and cardiometabolic risk of body mass excess.

METHODS

In this case-control study, 212 subjects with excess body mass and 145 normal-weight controls gave blood samples and underwent anthropometric and pulse wave analysis. Genotyping of gene was carried out to analyze the rs699947 (-2578 C/A) and rs2010963 (-634 G/C) SNPs. (ClinicalTrials.gov ID: NCT04077554).

RESULTS

This study showed a significant positive correlation between serum levels of VEGF-A and leptin in individuals with excess body mass possessing the CC genotype of the rs699947 variant of the gene. It has been registered that an increase in VEGF-A serum level correlates with an increase in arterial stiffness in excess body mass patients harboring AA genotype of the rs699947 (-2578 C/A) variant of the gene. No differences in VEGF-A and leptin serum concentrations were noted between particular genotypes.

CONCLUSIONS

The CC genotype of the rs699947 variant of the gene promotes a positive interdependency between leptin and VEGF-A serum levels in subjects with excess body mass.