Yin Jun, Chen Yu, Zhang Zhi-Huang, Han Xin
Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei 230009, China.
Polymers (Basel). 2016 Jul 22;8(7):268. doi: 10.3390/polym8070268.
Although a number of tactics towards the fabrication and biomedical exploration of stimuli-responsive polymeric assemblies being responsive and adaptive to various factors have appeared, the controlled preparation of assemblies with well-defined physicochemical properties and tailor-made functions are still challenges. These responsive polymeric assemblies, which are triggered by stimuli, always exhibited reversible or irreversible changes in chemical structures and physical properties. However, simple drug/polymer nanocomplexes cannot deliver or release drugs into the diseased sites and cells on-demand due to the inevitable biological barriers. Hence, utilizing therapeutic or imaging agents-loaded stimuli-responsive block copolymer assemblies that are responsive to tumor internal microenvironments (pH, redox, enzyme, and temperature, etc.) or external stimuli (light and electromagnetic field, etc.) have emerged to be an important solution to improve therapeutic efficacy and imaging sensitivity through rationally designing as well as self-assembling approaches. In this review, we summarize a portion of recent progress in tumor and intracellular microenvironment responsive block copolymer assemblies and their applications in anticancer drug delivery and triggered release and enhanced imaging sensitivity. The outlook on future developments is also discussed. We hope that this review can stimulate more revolutionary ideas and novel concepts and meet the significant interest to diverse readers.
尽管已经出现了一些用于制备对各种因素具有响应性和适应性的刺激响应性聚合物组装体并进行生物医学探索的策略，但制备具有明确物理化学性质和定制功能的组装体仍然是挑战。这些由刺激引发的响应性聚合物组装体，其化学结构和物理性质总是会发生可逆或不可逆的变化。然而，由于不可避免的生物屏障，简单的药物/聚合物纳米复合物无法按需将药物递送至患病部位和细胞或在其中释放药物。因此，利用负载治疗剂或成像剂的、对肿瘤内部微环境（pH、氧化还原、酶和温度等）或外部刺激（光和电磁场等）有响应的刺激响应性嵌段共聚物组装体，已成为通过合理设计和自组装方法提高治疗效果和成像灵敏度的重要解决方案。在这篇综述中，我们总结了肿瘤和细胞内微环境响应性嵌段共聚物组装体的部分最新进展及其在抗癌药物递送、触发释放和增强成像灵敏度方面的应用。还讨论了未来发展的前景。我们希望这篇综述能够激发更多具有革命性的想法和新颖的概念，并满足不同读者的浓厚兴趣。
