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用于瘢痕疙瘩和疤痕治疗的硅基双层贴片的物理和力学评估

Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy.

作者信息

Mikolaszek Barbara, Jamrógiewicz Marzena, Mojsiewicz-Pieńkowska Krystyna, Żebrowska Maria, Sznitowska Małgorzata, Strankowska Justyna

机构信息

Department of Pharmaceutical Technology, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdansk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.

Department of Physical Chemistry, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdansk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.

出版信息

Polymers (Basel). 2016 Nov 22;8(11):398. doi: 10.3390/polym8110398.

Abstract

Growing interest in silicone elastomers for pharmaceutical purposes is due to both their beneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical and mechanical properties, morphology, and stability. DLASil suitability for treatment of scars and keloids was evaluated by measurement of tensile strength, elasticity modulus, and elongation. The results indicated that mechanical and physical properties of the developed product were satisfying.

摘要

人们对用于制药目的的硅酮弹性体的兴趣日益浓厚,这既归因于它们对疤痕治疗有益的材料效应,也归因于它们作为药物载体的潜力。就其形态结构而言,硅酮聚合物具有独特的性能,这使得其具有广泛的应用可能性。本研究专注于通过评估其物理和机械性能、形态和稳定性来开发一种双层粘性硅酮膜(DLASil)。通过测量拉伸强度、弹性模量和伸长率来评估DLASil对疤痕和瘢痕疙瘩治疗的适用性。结果表明,所开发产品的机械和物理性能令人满意。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/6431886/5ab16afc4700/polymers-08-00398-g001.jpg

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