Kristó Katalin, Módra Szilvia, Hornok Viktória, Süvegh Károly, Ludasi Krisztina, Aigner Zoltán, Kelemen András, Sovány Tamás, Pintye-Hódi Klára, Regdon Géza
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, H-6720 Szeged, Hungary.
Department of Physical Chemistry and Materials Science, University of Szeged, H-6720 Szeged, Hungary.
Pharmaceutics. 2022 Feb 1;14(2):345. doi: 10.3390/pharmaceutics14020345.
Nowadays, the buccal administration of mucoadhesive films is very promising. Our aim was to prepare ascorbic acid-containing chitosan films to study the properties and structures important for applicability and optimize the composition. During the formulation of mucoadhesive films, chitosan as the polymer basis of the film was used. Ascorbic acid, which provided the acidic pH, was used in different concentrations (2-5%). The films were formulated by the solvent casting method. The properties of films important for applicability were investigated, such as physical parameters, mucoadhesive force, surface free energy, and breaking strength. The fine structure of the films was analyzed by atomic force microscopy, and the free volume was analyzed by PALS, which can be important for drug release kinetics and the location of the drug in the film. The applicability of the optimized composition was also tested with two different types of active ingredients. The structure of the films was also analyzed by XRPD and FTIR. Ascorbic acid can be used well in chitosan films, where it can function as a permeation enhancer when reacting to chitosan, it is biodegradable, and can be applied in 2% of our studies.
如今，粘膜粘附膜的口腔给药极具前景。我们的目标是制备含抗坏血酸的壳聚糖膜，以研究对适用性至关重要的性质和结构，并优化其组成。在制备粘膜粘附膜的过程中，使用壳聚糖作为膜的聚合物基质。提供酸性pH值的抗坏血酸以不同浓度（2 - 5%）使用。通过溶剂浇铸法制备薄膜。研究了对适用性重要的薄膜性质，如物理参数、粘膜粘附力、表面自由能和断裂强度。通过原子力显微镜分析薄膜的精细结构，通过正电子湮没寿命谱（PALS）分析自由体积，这对于药物释放动力学和药物在薄膜中的位置可能很重要。还使用两种不同类型的活性成分测试了优化组成的适用性。通过X射线粉末衍射（XRPD）和傅里叶变换红外光谱（FTIR）分析薄膜的结构。抗坏血酸在壳聚糖膜中能很好地发挥作用，当它与壳聚糖反应时可作为渗透促进剂，它是可生物降解的，并且在我们的研究中可使用2%的量。
