Department of Microbiology, School of Medicine, University of Valencia and Clinical Microbiology Service, Hospital Clínico Universitario de Valencia, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.
Viruses. 2019 Apr 10;11(4):339. doi: 10.3390/v11040339.
Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations. In order to evaluate the role of HBGAs in rotavirus infections in our population, secretor status (FUT2+), ABO blood group, and Lewis antigens were determined in children attended for rotavirus gastroenteritis in Valencia, Spain. During three consecutive years (2013-2015), stool and saliva samples were collected from 133 children with rotavirus infection. Infecting viral genotypes and HBGAs were determined in patients and compared to a control group and data from blood donors. Rotavirus G9P[8] was the most prevalent strain (49.6%), followed by G1P[8] (20.3%) and G12P[8] (14.3%). Rotavirus infected predominantly secretor (99%) and Lewis b positive (91.7%) children. Children with blood group A and AB were significantly more prone to rotavirus gastroenteritis than those with blood group O. Our results confirm that a HBGA genetic background is linked to rotavirus P[8] susceptibility. Rotavirus P[8] symptomatic infection is manifestly more frequent in secretor-positive (FUT2+) than in non-secretor individuals, although no differences between rotavirus G genotypes were found.
A 组轮状病毒是导致儿童急性肠胃炎的主要原因。轮状病毒基因型的多样性和地理分布不均与不同人群的组织血型抗原（HBGAs）有关。为了评估 HBGAs 在我们人群中轮状病毒感染中的作用，我们在西班牙瓦伦西亚因轮状病毒肠胃炎就诊的儿童中确定了分泌状态（FUT2+）、ABO 血型和 Lewis 抗原。在连续三年（2013-2015 年）中，我们从 133 名感染轮状病毒的儿童中收集了粪便和唾液样本。在患者中确定了感染的病毒基因型和 HBGAs，并与对照组和献血者的数据进行了比较。轮状病毒 G9P[8]是最常见的菌株（49.6%），其次是 G1P[8]（20.3%）和 G12P[8]（14.3%）。轮状病毒主要感染分泌者（99%）和 Lewis b 阳性（91.7%）的儿童。与 O 型血的儿童相比，A 型和 AB 型血的儿童更容易患轮状病毒肠胃炎。我们的结果证实，HBGA 遗传背景与轮状病毒 P[8]易感性有关。在 FUT2+（分泌者阳性）个体中，轮状病毒 P[8]症状性感染明显比非分泌者更常见，尽管在轮状病毒 G 基因型之间没有发现差异。
