Kaur Paramvir, Gupta Madhu, Sagar Vivek
Department of Community Medicine and Public Health, Postgraduate Institute of Medical Education and Research Chandigarh, India.
Int J Mol Epidemiol Genet. 2022 Jun 15;13(1):1-14. eCollection 2022.
Some blood group antigens are reported as a susceptibility marker for some diseases. For instance, HBGA (Histo-blood group antigen) which is controlled by gene FUT2 also considered as a susceptible marker. The FUT2 gene which exhibits the expression of alpha-1, 2-L-fucosyltransferase enzyme also leads to HBGA expression for the gut, and it provides a composition of the phenotypical profile that exists in some populations with unique histories of evolution and it can be considered as a marker of the genetic population. It is found to have an association with many diseases which is discussed in this review. Polymorphic mutations are known to inhibit and reduce its function which are population specific. Detailed understanding and deeper knowledge of its role in the pathogenesis and prevention of many diseases is required. FUT2 may also have a potential role in the case of COVID-19 as a susceptible marker due to its association with respiratory diseases and the ABO blood group. There is an utmost need for this kind of review knowing its importance and owing to limited collective information.
一些血型抗原被报道为某些疾病的易感性标志物。例如，由FUT2基因控制的组织血型抗原（HBGA）也被视为一种易感性标志物。表现出α-1,2-L-岩藻糖基转移酶表达的FUT2基因也会导致肠道中HBGA的表达，它提供了一些具有独特进化历史的人群中存在的表型特征组成，并且可以被视为遗传群体的一个标志物。本文综述讨论了它与许多疾病的关联。已知多态性突变会抑制并降低其功能，这些突变具有人群特异性。需要对其在多种疾病的发病机制和预防中的作用有更详细的了解和更深入的认识。由于FUT2与呼吸系统疾病以及ABO血型的关联，它在新冠肺炎病例中作为易感性标志物可能也具有潜在作用。鉴于此类综述的重要性以及现有有限的综合信息，对其有着极大的需求。
